3.4.21.112: site-1 protease

This is an abbreviated version!
For detailed information about site-1 protease, go to the full flat file.

Word Map on EC 3.4.21.112

3.4.21.112

srebps

proprotein

furin

site-2

atf6

subtilase

lassa

arenaviruses

medicine

cleavage-activating

mbtps1

nonbasic

crimean-congo

mucolipidosis

glcnac-1-phosphotransferase

n-acetylglucosamine-1-phosphotransferase

degradation

Reaction

processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3 =

Synonyms

convertase site 1 protease, dS1P, hSKI-1, kexin, membrane-bound transcription factor protease, site-1, MEROPS S08.8063, PCSK8, prohormone convertase subtilisin-kexin isoenzyme-1, protease responsible for activating sigmaW, PrsW, S08.063, S1P, site 1 protease, site-1 protease, SK-1, SKI-1, SKI-1/S1P, SREBP site 1 protease, subtilisin kexin isoenzyme-1, subtilisin kexin isozyme 1/site 1 protease, subtilisin kexin isozyme-1, subtilisin kexin isozyme-1(SK-1)/site 1 protease (S1P), subtilisin kexin isozyme-1/site-1 protease, subtilisin kexin-isozyme-1, subtilisin-kexin isoenzyme-1, subtilisin-kexin-isozyme, subtilisin/kexin isozyme 1, YPDC

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.112 site-1 protease

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Results	in table
4	Activating Compound
37	AA Sequence
15	Application
1	CAS Registry Number
19	Cloned(Commentary)
126	Disease/ Diagnostics
17	General Information
26	IC50 Value
70	Inhibitors
11	Ki Value [mM]
37	KM Value [mM]
26	Localization
8	Metals/Ions
9	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
61	Organism
4	pH Optimum
11	Posttranslational Modification
39	Protein Variants
4	Purification (Commentary)
1	Reaction
18	Reaction Type
53	Reference
55	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
82	Substrates and Products (Substrate)
1	Subunits
81	Synonyms
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.21.112 - site-1 protease

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0.0051

2-aminobenzoic acid-SSGSRRLLSEESY(NO2)-Ala-NH2

Homo sapiens

pH 7.4

653076

0.028

2-aminobenzoyl-Arg-Asn-Thr-Pro-Arg-Arg-Glu-Arg-Arg-Arg-Lys-Lys-Arg-Gly-Leu-(3-nitro)Tyr-Ala

Homo sapiens

pH 7.4, 37°C

651295

0.02

2-aminobenzoyl-Arg-His-Ser-Ser-Arg-Arg-Leu-Leu-Arg-Ala-Ile-(3-nitro)Tyr-Ala

Homo sapiens

pH 7.4, 37°C

651295

0.00096

2-aminobenzoyl-Arg-Ser-Leu-Lys-Tyr-Ala-Glu-Ser-Asp-(3-nitro)Tyr-Ala

Homo sapiens

pH 7.4, 37°C

651295

0.0044

2-aminobenzoyl-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu-Gly-Thr-Phe-Thr-(3-nitro)Tyr-Ala

Homo sapiens

pH 7.4, 37°C

651295

0.023

2-aminobenzoyl-Ser-Arg-Arg-Leu-Leu-Arg-Ala-Leu-Glu-(3-nitro)Tyr-Ala

Homo sapiens

pH 7.4, 37°C

651295

0.00428

2-aminobenzoyl-Val-Phe-Arg-Ser-Leu-Lys-Tyr-Ala-Glu-Ser-Asp-(3-nitro)Tyr-Ala

Homo sapiens

pH 7.4, 37°C

651295

0.0031

Abz-DIYISRRLLGTFTY(NO2)A

Homo sapiens

689857

0.0504 - 0.067

Ac-AISRRLL-7-amido-4-methylcoumarin

2 entries

0.0255

Ac-Arg-Arg-Leu-Leu-p-nitroanilide

Homo sapiens

689857

0.1335

Ac-Arg-Ser-Leu-Lys-p-nitroanilide

Homo sapiens

689857

0.0123 - 0.015

Ac-FISRRLL-7-amido-4-methylcoumarin

2 entries

0.0226 - 0.0846

Ac-IAVGRTLK-7-amido-4-methylcoumarin

2 entries

0.0047 - 0.0074

Ac-IYISRRLL-7-amido-4-methylcoumarin

2 entries

0.0025 - 0.0156

Ac-QKSIAVGRTLK-7-amido-4-methylcoumarin

2 entries

0.0274 - 0.0564

Ac-RKLL-7-amido-4-methylcoumarin

2 entries

0.0153 - 0.0228

Ac-RRLL-7-amido-4-methylcoumarin

2 entries

0.0971 - 0.2263

Ac-RRLQ-7-amido-4-methylcoumarin

2 entries

0.0967 - 0.2167

Ac-RTLK-7-amido-4-methylcoumarin

2 entries

0.0443 - 0.0784

Ac-SFITRRLQ-7-amido-4-methylcoumarin

2 entries

0.1

Ac-VFRSLK-4-methyl-coumaryl-7-amide

Mammalia

pH 8, 37°C

651939

0.0028 - 0.0057

Ac-YISRRLL-7-amido-4-methylcoumarin

4 entries

0.0212 - 0.0281

Ac-YSSVSRKLL-7-amido-4-methylcoumarin

2 entries