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3.4.21.112: site-1 protease

This is an abbreviated version!
For detailed information about site-1 protease, go to the full flat file.

Word Map on EC 3.4.21.112

Reaction

processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3 =

Synonyms

convertase site 1 protease, dS1P, hSKI-1, kexin, membrane-bound transcription factor protease, site-1, MEROPS S08.8063, PCSK8, prohormone convertase subtilisin-kexin isoenzyme-1, protease responsible for activating sigmaW, PrsW, S08.063, S1P, site 1 protease, site-1 protease, SK-1, SKI-1, SKI-1/S1P, SREBP site 1 protease, subtilisin kexin isoenzyme-1, subtilisin kexin isozyme 1/site 1 protease, subtilisin kexin isozyme-1, subtilisin kexin isozyme-1(SK-1)/site 1 protease (S1P), subtilisin kexin isozyme-1/site-1 protease, subtilisin kexin-isozyme-1, subtilisin-kexin isoenzyme-1, subtilisin-kexin-isozyme, subtilisin/kexin isozyme 1, YPDC

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.112 site-1 protease

Substrates Products

Substrates Products on EC 3.4.21.112 - site-1 protease

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(pro)renin receptor + H2O
soluble (pro)renin receptor + ?
show the reaction diagram
-
-
-
-
?
2-aminobenzoic acid-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu-Gly-Thr-Phe-Thr-(3-nitro)Tyr-Ala + H2O
2-aminobenzoic acid-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu + Gly-Thr-Phe-Thr-(3-nitro)Tyr-Ala
show the reaction diagram
-
cleaves between Leu and Gly
-
?
2-aminobenzoic acid-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu-Gly-Thr-Phe-Thr-3-nitrotyrosyl-Ala-CONH2 + H2O
2-aminobenzoic acid-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu + Gly-Thr-Phe-Thr-3-nitrotyrosyl-Ala-CONH2
show the reaction diagram
-
-
-
-
?
2-aminobenzoic acid-SSGSRRLLSEESY(NO2)-Ala-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
2-aminobenzoyl-ALVLRKPLFLDSY(NO2)-Ala + H2O
?
show the reaction diagram
-
cleaves between Leu and Phe
-
?
2-aminobenzoyl-Arg-Asn-Thr-Pro-Arg-Arg-Glu-Arg-Arg-Arg-Lys-Lys-Arg-Gly-Leu-(3-nitro)Tyr-Ala + H2O
2-aminobenzoyl-Arg-Asn-Thr-Pro-Arg-Arg-Glu-Arg-Arg-Arg-Lys-Lys-Arg-Gly-Leu + (3-nitro)Tyr-Ala
show the reaction diagram
-
cleaves between Leu and 3-nitrotyrosine
-
?
2-aminobenzoyl-Arg-His-Ser-Ser-Arg-Arg-Leu-Leu-Arg-Ala-Ile-(3-nitro)Tyr-Ala + H2O
2-aminobenzoyl-Arg-His-Ser-Ser-Arg-Arg-Leu-Leu + Arg-Ala-Ile-(3-nitro)Tyr-Ala
show the reaction diagram
-
cleaves between Leu and Arg
-
?
2-aminobenzoyl-Arg-Ser-Leu-Lys-Tyr-Ala-Glu-Ser-Asp-(3-nitro)-Tyr-Ala + H2O
2-aminobenzoyl-Arg-Ser-Leu-Lys + Tyr-Ala-Glu-Ser-Asp-(3-nitro)-Tyr-Ala
show the reaction diagram
-
cleaves between Lys and Tyr
-
?
2-aminobenzoyl-Ser-Arg-Arg-Leu-Leu-Arg-Ala-Leu-Glu-(3-nitro)Tyr-Ala + H2O
2-aminobenzoyl-Ser-Arg-Arg-Leu-Leu + Arg-Ala-Leu-Glu-(3-nitro)Tyr-Ala
show the reaction diagram
-
cleaves between Leu and Arg
-
?
2-aminobenzoyl-SSGSRRLLSEESY(NO2)-Ala + H2O
?
show the reaction diagram
-
cleaves between Leu and Ser
-
?
2-aminobenzoyl-Val-Phe-Arg-Ser-Leu-Lys-Tyr-Ala-Glu-Ser-Asp-(3-nitro)Tyr-Ala + H2O
2-aminobenzoyl-Val-Phe-Arg-Ser-Leu-Lys + Tyr-Ala-Glu-Ser-Asp-(3-nitro)Tyr-Ala
show the reaction diagram
-
cleaves between Lys and Tyr
-
?
Abz-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu-Gly-Thr-Phe-Thr-(3-nitro)Tyr-Ala-CONH2 + H2O
Abz-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu + Gly-Thr-Phe-Thr-(3-nitro)Tyr-Ala-CONH2
show the reaction diagram
-
i.e. QPC251-263
-
-
?
Abz-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu-Gly-Thr-Phe-Thr-(3-nitro)Tyr-Ala-NH2 + H2O
?
show the reaction diagram
-
favored quenched fluorogenic substrate
-
-
?
Abz-DIYISRRLL-GTFT-Tyx-A + H2O
Abz-DIYISRRLL + GTFT-Tyx-A
show the reaction diagram
-
-
-
-
?
Abz-DIYISRRLLGTFTY(NO2)A + H2O
?
show the reaction diagram
-
S1P displays pronounced positive cooperativity with this substrate derived from the viral coat glycoprotein of the lassa virus
-
-
?
Ac-AISRRLL-7-amido-4-methylcoumarin + H2O
Ac-AISRRLL + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-Arg-Arg-Leu-Leu-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Ac-Arg-Ser-Leu-Lys-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Ac-FISRRLL-7-amido-4-methylcoumarin + H2O
Ac-FISRRLL + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-IAVGRTLK-7-amido-4-methylcoumarin + H2O
Ac-IAVGRTLK + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-IYISRRLL-7-amido-4-methylcoumarin + H2O
Ac-IYISRRLL + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-Leu-4-methyl-coumaryl-7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
Ac-QKSIAVGRTLK-7-amido-4-methylcoumarin + H2O
Ac-QKSIAVGRTLK + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-RKLL-7-amido-4-methylcoumarin + H2O
Ac-RKLL + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-RRLL-7-amido-4-methylcoumarin + H2O
Ac-RRLL + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-RRLQ-7-amido-4-methylcoumarin + H2O
Ac-RRLQ + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-RTLK-7-amido-4-methylcoumarin + H2O
Ac-RTLK + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-SFITRRLQ-7-amido-4-methylcoumarin + H2O
Ac-SFITRRLQ + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-VFRSLK-4-methyl-coumaryl-7-amide + H2O
?
show the reaction diagram
Ac-VFRSLK-4-methylcoumarin 7-amide
?
show the reaction diagram
-
-
-
?
Ac-VFRSLK-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
Ac-YISRRLL-7-amido-4-methylcoumarin + H2O
Ac-YISRRLL + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
Ac-YSSVSRKLL-7-amido-4-methylcoumarin + H2O
Ac-YSSVSRKLL + 7-amino-4-methylcoumarin
show the reaction diagram
an arenavirus envelope glycoprotein precursor protein-derived peptide substrate
-
-
?
arenavirus envelope glycoprotein precursor + H2O
?
show the reaction diagram
ATF6 + H2O
?
show the reaction diagram
ATF6 precursor + H2O
nuclear ATF6
show the reaction diagram
-
rSt-1 and rSt-2 seem to affect the processing of ATF6 by SKI-1
-
-
?
brain-derived neurotrophic factor precursor + H2O
?
show the reaction diagram
-
cleaves at an RGLTLS site between Thr and Ser
-
?
CREB4 + H2O
?
show the reaction diagram
-
i.e. androgen-induced leucine zipper protein, C-terminal domain of CREB4 somehow confers resistance to cleavage by S1P, which can be released either by removal of the region or physiologically by some regulatory signal
-
-
?
Crimean Congo hemorrhagic fever virus glycoprotein + H2O
?
show the reaction diagram
Crimean Congo hemorrhagic fever virus glycoprotein + H2O
glycoprotein precursor Gn + glycoprotein precursor Gc
show the reaction diagram
-
-
-
-
?
Dabcyl-Arg-His-Ser-Ser-Arg-Arg-Leu-Leu-Arg-Ala-Leu-Glu-Gly-Gly-Lys(tetramethylrhodamine)-OH + H2O
?
show the reaction diagram
-
-
-
?
Dabcyl-Ser-Gly-Ser-Gly-Arg-Ser-Val-Leu-Ser-Phe-Glu-Ser-Gly-Ser-Lys(tetramethylrhodamine)-Arg-OH + H2O
?
show the reaction diagram
-
-
-
?
glycoprotein + H2O
?
show the reaction diagram
-
S1P is involved in the processing of the glycoproteins of the genetically more-distant South American hemorrhagic fever viruses Guanarito, Machupo, and Junin
-
-
?
glycoprotein precursor Gc + H2O
?
show the reaction diagram
glycoprotein precursor Gn + H2O
?
show the reaction diagram
-
-
-
-
?
Lassa virus envelope glycoprotein precursor + H2O
?
show the reaction diagram
the enzyme recognition motif RRLL is critical for the processing of the Lassa virus envelope glycoprotein in the endoplasmic reticulum/cis-Golgi compartment
-
-
?
Lassa virus glycoprotein + H2O
?
show the reaction diagram
-
cleavage at RRLL-sites
-
-
?
Lassa virus glycoprotein precursor GP-C + H2O
Lassa virus glycoprotein GP-2 + ?
show the reaction diagram
-
cleavage at the C-terminal end of the recognition motif R-R-L-L
-
-
?
Lassa virus glycoprotein precursor protein + H2O
peripheral virion attachment protein GP1 + fusion-active transmembrane protein GP2
show the reaction diagram
-
-
Arg-Arg-Leu-Leu + Gly-Thr-Phe
-
?
lymphocytic choriomeningitis virus glycoprotein precursor protein + H2O
peripheral virion attachment protein GP1 + fusion-active transmembrane protein GP2
show the reaction diagram
-
-
Arg-Arg-Leu-Ala + Gly-Thr-Phe
-
?
membrane-associated transcription factor bZIP28 + H2O
?
show the reaction diagram
RsiW + H2O
?
show the reaction diagram
sterol regulatory element-binding protein + H2O
?
show the reaction diagram
sterol regulatory element-binding protein SREBP-2 + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-YISRRLL-7-amido-4-methylcoumarin + H2O
succinyl-YISRRLL + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
additional information
?
-