3.4.19.3: pyroglutamyl-peptidase I
This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase I, go to the full flat file.
Word Map on EC 3.4.19.3
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3.4.19.3
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trh
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lymphocyte
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thymocytes
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thyrotropin-releasing
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cd8
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thyrotropin
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trh-degrading
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amyloliquefaciens
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deblocked
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analysis
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thyroliberin
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his-pro
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diketopiperazine
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l-pyroglutamic
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phytolacca
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hermes
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pancreatitis-associated
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adipokinetic
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litoralis
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post-proline
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protein-i
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cyclo
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3.4.21.26
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luliberin
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intrathymic
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medicine
- 3.4.19.3
- trh
- lymphocyte
- thymocytes
-
thyrotropin-releasing
- cd8
- thyrotropin
-
trh-degrading
- amyloliquefaciens
-
deblocked
- analysis
- thyroliberin
- his-pro
-
diketopiperazine
-
l-pyroglutamic
- phytolacca
- hermes
-
pancreatitis-associated
-
adipokinetic
- litoralis
-
post-proline
- protein-i
-
cyclo
-
3.4.21.26
- luliberin
-
intrathymic
- medicine
Reaction
release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro =
Synonyms
5-oxoprolyl-peptidase, aminopeptidase, pyroglutamate, cysteine-free PCP, EC 3.4.11.8, L-pyrrolidonecarboxylate peptidase, PAP, PAP-I, PAP1, PCP, PCP-0SH, PGAP, PGP I, PGP-1, PGPEP1, PPI, PYR, PYRase, pyroglutamate aminopeptidase, pyroglutamidase, pyroglutamyl aminopeptidase, pyroglutamyl aminopeptidase I, pyroglutamyl peptidase I, pyroglutamyl peptidase type-1, pyroglutamyl type I aminopeptidase, pyroglutamyl-peptidase 1, pyroglutamylaminopeptidase, pyrrolidone carboxyeptidase, pyrrolidone carboxyl peptidase, pyrrolidone carboxypeptidase type I, pyrrolidone-carboxylate peptidase, pyrrolidonecarboxy peptidase, pyrrolidonecarboxylyl peptidase, pyrrolidonyl arylamidase, pyrrolidonyl peptidase
ECTree
3.4.19.3 pyroglutamyl-peptidase IAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.4.19.3 - pyroglutamyl-peptidase I
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
pyroglutamyl-peptide + H2O
pyroglutamate + peptide
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the enzyme is able to specifically remove the amino-terminal pyroglutamyl residue protecting proteins or peptides from aminopeptidases
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?
thyrotrophin-releasing hormone + H2O
?
trypanosomal pyroglutamyl aminopeptidase I is responsible for the abnormally rapid degradation of thyrotrophin-releasing hormone in the circulation of infected rats
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?
thyrotrophin releasing hormone
?
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the enzyme is proposed to inactivate thyrotrophin releasing hormone in brain extracellular space
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-
?
additional information
?
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the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
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?
additional information
?
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the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
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-
?
additional information
?
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the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
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-
?
additional information
?
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-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
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-
?
additional information
?
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-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
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?
additional information
?
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enzyme may participate in regulating the levels of seminal thyrotropin-relasing hormone analogues and in mediating sperm death associated with necrozoospermia
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?
additional information
?
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the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
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-
?
additional information
?
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pyroglutamate and iron regulate the expression of the enzyme
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-
?
additional information
?
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pyroglutamate and iron regulate the expression of the enzyme
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-
?
additional information
?
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the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
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-
?
additional information
?
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diurnal variation and left-right distribution of pyroglutamyl peptidase I activity in the rat brain and retina
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-
?
additional information
?
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pyroglutamyl peptidase I levels and their left-right distribution in the rat retina and hypothalamus are influenced by light-dark conditions
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?
additional information
?
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the enzyme might not be dominantly involved in the degradation of thyrotropin-releasing hormone in rats
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-
?
additional information
?
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-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
additional information
?
-
-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
