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3.4.19.3: pyroglutamyl-peptidase I

This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase I, go to the full flat file.

Word Map on EC 3.4.19.3

Reaction

release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro =

Synonyms

5-oxoprolyl-peptidase, aminopeptidase, pyroglutamate, cysteine-free PCP, EC 3.4.11.8, L-pyrrolidonecarboxylate peptidase, PAP, PAP-I, PAP1, PCP, PCP-0SH, PGAP, PGP I, PGP-1, PGPEP1, PPI, PYR, PYRase, pyroglutamate aminopeptidase, pyroglutamidase, pyroglutamyl aminopeptidase, pyroglutamyl aminopeptidase I, pyroglutamyl peptidase I, pyroglutamyl peptidase type-1, pyroglutamyl type I aminopeptidase, pyroglutamyl-peptidase 1, pyroglutamylaminopeptidase, pyrrolidone carboxyeptidase, pyrrolidone carboxyl peptidase, pyrrolidone carboxypeptidase type I, pyrrolidone-carboxylate peptidase, pyrrolidonecarboxy peptidase, pyrrolidonecarboxylyl peptidase, pyrrolidonyl arylamidase, pyrrolidonyl peptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.3 pyroglutamyl-peptidase I

Turnover Number

Turnover Number on EC 3.4.19.3 - pyroglutamyl-peptidase I

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.8 - 2.3
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide
9 - 12
gonadotropin-releasing hormone
2.4 - 3.6
L-2-oxoimidazolidine-4-carboxyl-L-Ala
7.6
L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate
-
37°C, pH 7.4
6.4 - 8.1
L-2-oxooxazolidine-4-carboxyl-L-Ala
1.5
L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate
-
37°C, pH 7.4
0.9
L-2-oxothiazolidine-4-carboxyl-ethanolamine
-
37°C, pH 7.4
3.2
L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate
-
37°C, pH 7.4
2.3 - 3.4
L-2-oxothiazolidine-4-carboxyl-L-Ala
47 - 58
L-pyroglutamyl-7-amido-4-methylcoumarin
3.5
L-pyroglutamyl-aminoethylnitrate
-
37°C, pH 7.4
0.5 - 785
L-pyroglutamyl-beta-naphthylamide
2.4 - 3.7
L-pyroglutamyl-L-Ala
52 - 64
L-pyroglutamyl-p-nitroanilide
7.2
luteinizing-hormone-releasing hormone
-
-
26.3
neurotensin
-
-
3.5
pyroglutamic acid-7-amido-4-methylcoumarin
-
-
7.4 - 35.1
Pyroglutamyl-beta-naphthylamide
21
thyroliberin-releasing hormone
-
-
-
20 - 22
thyrotrophin-releasing hormone