3.4.14.9: tripeptidyl-peptidase I

This is an abbreviated version!
For detailed information about tripeptidyl-peptidase I, go to the full flat file.

Reaction

Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity =

Synonyms

aminopeptidase, tripeptidyl, I, AO090166000084, ceroid lipofuscinosis 2 protease, CLN2, CLN2 protein, CLN2p, EC 3.4.14.8, LPIC, lysosomal pepstatin insensitive protease, N-terminal tripeptidyl exopeptidase, SedB, SedC, SedD, sedolisin B, sedolisin C, sedolisin D, TPP I, TPP-I, Tpp1, TPP1F, TPPI, tripeptidyl aminopeptidase, tripeptidyl aminopeptidase I, tripeptidyl exopeptidase, tripeptidyl peptidase, tripeptidyl peptidase 1, tripeptidyl peptidase I, tripeptidyl peptidase-I, tripeptidyl-peptidase 1, tripeptidyl-peptidase I, TTP-I, v4-7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

                3.4.14.9 tripeptidyl-peptidase I

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Results	in table
3	Activating Compound
1114	AA Sequence
7	Application
1	CAS Registry Number
19	Cloned(Commentary)
2	Crystallization (Commentary)
363	Disease/ Diagnostics
17	General Information
3	General Stability
5	IC50 Value
67	Inhibitors
3	kcat/KM [mM/s]
8	Ki Value [mM]
32	KM Value [mM]
35	Localization
5	Metals/Ions
25	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
60	Organism
3	PDB ID
23	pH Optimum
10	pH Range
9	pH Stability
3	pI Value
17	Posttranslational Modification
64	Protein Variants
14	Purification (Commentary)
3	Reaction
1	Reaction Type
60	Reference
93	Source Tissue
5	Specific Activity [micromol/min/mg]
2	Storage Stability
123	Substrates and Products (Substrate)
11	Subunits
100	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
32	Turnover Number [1/s]

Application

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Application on EC 3.4.14.9 - tripeptidyl-peptidase I

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

Homo sapiens

O14773

development of fluorescence resonance energy transfer peptides using tryptophan as the fluorophore to study TPP-I hydrolytic properties. Assay can be applied to spleen and kidney homogenate

754998

diagnostics

2 entries

medicine

3 entries

molecular biology

Rattus norvegicus

-

fluorescent method for the histochemical detection of tripeptidyl peptidase I using glycyl-L-prolyl-L-Met-2-anthraquinonyl hydrazide as substrate

664560

diagnostics

Homo sapiens

-

potential markers for Sjoegren's syndrome

664615

diagnostics

Homo sapiens

-

saliva is a reliable and non-invasive source for the diagnosis of infantile (CLN1) and late infantile (CLN2) neuronal ceroid lipofuscinoses

664616

medicine

Chlorocebus sabaeus

-

adeno-associated virus 2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for late infantile neuronal ceroid lipofuscinosis

665046

medicine

Homo sapiens

-

[Ala-Ala-Phe]2-rhodamine 110 and [Arg-Nle-Nle]2-rhodamine 110 are specific substrate for determining TPP-I activity and intracellular localization in living cells. These substrates can be a valuable tool for studying the neuronal pathology underlying classical late-infantile neuronal ceroid lipofuscinosis

665906

medicine

Homo sapiens

-

mutations in tripeptidyl-peptidase I underlie the classic late-infantile form of neuronal ceroid lipofuscinoses (CLN2), the most common neurodegenerative disorders of childhood

678513