3.4.14.9: tripeptidyl-peptidase I

This is an abbreviated version!
For detailed information about tripeptidyl-peptidase I, go to the full flat file.

Reaction

Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity =

Synonyms

aminopeptidase, tripeptidyl, I, AO090166000084, ceroid lipofuscinosis 2 protease, CLN2, CLN2 protein, CLN2p, EC 3.4.14.8, LPIC, lysosomal pepstatin insensitive protease, N-terminal tripeptidyl exopeptidase, SedB, SedC, SedD, sedolisin B, sedolisin C, sedolisin D, TPP I, TPP-I, Tpp1, TPP1F, TPPI, tripeptidyl aminopeptidase, tripeptidyl aminopeptidase I, tripeptidyl exopeptidase, tripeptidyl peptidase, tripeptidyl peptidase 1, tripeptidyl peptidase I, tripeptidyl peptidase-I, tripeptidyl-peptidase 1, tripeptidyl-peptidase I, TTP-I, v4-7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

                3.4.14.9 tripeptidyl-peptidase I

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Results	in table
3	Activating Compound
1114	AA Sequence
7	Application
1	CAS Registry Number
19	Cloned(Commentary)
2	Crystallization (Commentary)
363	Disease/ Diagnostics
17	General Information
3	General Stability
5	IC50 Value
67	Inhibitors
3	kcat/KM [mM/s]
8	Ki Value [mM]
32	KM Value [mM]
35	Localization
5	Metals/Ions
25	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
60	Organism
3	PDB ID
23	pH Optimum
10	pH Range
9	pH Stability
3	pI Value
17	Posttranslational Modification
64	Protein Variants
14	Purification (Commentary)
3	Reaction
1	Reaction Type
60	Reference
93	Source Tissue
5	Specific Activity [micromol/min/mg]
2	Storage Stability
123	Substrates and Products (Substrate)
11	Subunits
100	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
32	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.14.9 - tripeptidyl-peptidase I

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.06

Ala-Ala-Phe-CH2Cl

Rattus norvegicus

-

IC50: 0.06 mM

647183

1.15

diisopropylfluorophosphate

Rattus norvegicus

-

IC50: 1.15 mM

647183

0.67

Hg2+

Rattus norvegicus

-

1 mM, complete inhibition, IC50: 0.67 mM

647183

0.27

p-chloromercuribenzene sulfonic acid

Rattus norvegicus

-

IC50: 0.27 mM

647183

0.0001292

prosegment of tripeptidyl peptidase I

Homo sapiens

-

in sodium acetate buffer (50 mM, pH 5.0), 0.05% Triton X-100

698756

-