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3.4.14.9: tripeptidyl-peptidase I

This is an abbreviated version!
For detailed information about tripeptidyl-peptidase I, go to the full flat file.

Word Map on EC 3.4.14.9

Reaction

Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity =

Synonyms

aminopeptidase, tripeptidyl, I, AO090166000084, ceroid lipofuscinosis 2 protease, CLN2, CLN2 protein, CLN2p, EC 3.4.14.8, LPIC, lysosomal pepstatin insensitive protease, N-terminal tripeptidyl exopeptidase, SedB, SedC, SedD, sedolisin B, sedolisin C, sedolisin D, TPP I, TPP-I, Tpp1, TPP1F, TPPI, tripeptidyl aminopeptidase, tripeptidyl aminopeptidase I, tripeptidyl exopeptidase, tripeptidyl peptidase, tripeptidyl peptidase 1, tripeptidyl peptidase I, tripeptidyl peptidase-I, tripeptidyl-peptidase 1, tripeptidyl-peptidase I, TTP-I, v4-7

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.9 tripeptidyl-peptidase I

pH Range

pH Range on EC 3.4.14.9 - tripeptidyl-peptidase I

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1.5 - 6
active between pH 3 and pH 7, SedD
2 - 5
-
-
3 - 4.5
higher endopeptidase activity at pH 3.0 compared to pH 4.5
3 - 4.8
-
pH 3.0: about 30% of maximal activity, pH 4.8: about 50% of maximal activity
3 - 7
3 - 8
-
about half-maximal activity at pH 3 and 8, hydrolysis of Gly-Pro-Met 2-naphthylamide
3.5 - 5
-
pH 3.5: about 25% of maximal activity, pH 5.0: about 45% of maximal activity, hydrolysis of Ala-Ala-Phe-7-amido-4-methylcoumarin
3.5 - 6.5
-
about half-maximal activity at pH 3.5 and 6.5, hydrolysis of Ala-Ala-Phe 4-methylcoumarin 7-amide
4 - 5.5
about 55% of maximal activity at pH 4.0 and at pH 5.5, hydrolysis of Ala-Ala-Phe-7-amido-4-methylcoumarin