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3.4.14.9: tripeptidyl-peptidase I

This is an abbreviated version!
For detailed information about tripeptidyl-peptidase I, go to the full flat file.

Word Map on EC 3.4.14.9

Reaction

Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity =

Synonyms

aminopeptidase, tripeptidyl, I, AO090166000084, ceroid lipofuscinosis 2 protease, CLN2, CLN2 protein, CLN2p, EC 3.4.14.8, LPIC, lysosomal pepstatin insensitive protease, N-terminal tripeptidyl exopeptidase, SedB, SedC, SedD, sedolisin B, sedolisin C, sedolisin D, TPP I, TPP-I, Tpp1, TPP1F, TPPI, tripeptidyl aminopeptidase, tripeptidyl aminopeptidase I, tripeptidyl exopeptidase, tripeptidyl peptidase, tripeptidyl peptidase 1, tripeptidyl peptidase I, tripeptidyl peptidase-I, tripeptidyl-peptidase 1, tripeptidyl-peptidase I, TTP-I, v4-7

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.9 tripeptidyl-peptidase I

Cloned

Cloned on EC 3.4.14.9 - tripeptidyl-peptidase I

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
C-terminal hexahistidine-tagged human CLN2p/tripeptidyl-peptidase I produced from insect cells transfected with a baculovirus vector
expressed in Chinese hamster ovary cells
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expressed in CHO cells
expressed in HEK-293 cells
expressed in Mus musculus brain
expressed in Rattus norvegicus brain
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expression as fusion protein with enhanced green fluorescent protein, in Aspergillus oryzae
expression in Chinese hamster ovary cells under the control of the cytomegalovirus promoter
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expression in silkworm pupae
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expression of mutant enzymes in HEK cells and CHO cells
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expression of mutant enzymes N210Q, N222Q, N286Q, N313Q and N443N in Chinese hamster overy cells and human embryonic kidney 293 cells
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expression of SedB in Pichia pastoris
expression of SedC in Pichia pastoris
expression of SedD in Pichia pastoris
expression of wild-type and mutant enzymes (E272A, D276A, D327A, D360A and S475L) in CHO cells
gene v4-7 or tpp1F, vegetative stage-specific mRNA 4-7, located on chromosome 3, recombinant expression of C-terminally GFP-tagged isozyme TPPIF(1-702) in Dictyostelium discoideum strain AX2
TPP I prosegment is expressed in Escherichia coli BL21 (DE3) cells
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