3.4.13.19: membrane dipeptidase
This is an abbreviated version!
For detailed information about membrane dipeptidase, go to the full flat file.
Word Map on EC 3.4.13.19
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3.4.13.19
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carbapenems
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cilastatin
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imipenem
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beta-defensins
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phosphatidylinositol-specific
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meropenem
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dehydropeptidase-i
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microvillar
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carnosine
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thienamycin
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medicine
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nutrition
- 3.4.13.19
- carbapenems
- cilastatin
- imipenem
- beta-defensins
-
phosphatidylinositol-specific
- meropenem
-
dehydropeptidase-i
- microvillar
- carnosine
- thienamycin
- medicine
- nutrition
Reaction
hydrolysis of dipeptides =
Synonyms
43 kDa renal band 3-related protein, aminodipeptidase, dehydropeptidase I (DPH I), DHP-I, dipeptidase, dipeptide hydrolase, dipeptidyl hydrolase, DPP9, EC 3.4.13.11, glycosyl-phosphatidylinositol-anchored renal dipeptidase, GPI-renal dipeptidase, LDP, lysosomal dipeptidase, MBD, MBD-1, MBD-2, MBD-3, MDP, membrane-associated dipeptidase, microsomal MBD, nonspecific dipeptidase, PepD, PepV, RDP, RDPase, renal dipeptidase, Sco3058, Ser-Met dipeptidase, tissue carnosinase
ECTree
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Inhibitors
Inhibitors on EC 3.4.13.19 - membrane dipeptidase
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(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-(trifluoromethyl)phenyl)acrylic acid
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50% inhibition at 10 nM
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-bromophenyl)acrylic acid
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50% inhibition at 6 nM
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-fluorophenyl)acrylic acid
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50% inhibition at 5 nM
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-iodophenyl)acrylic acid
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50% inhibition at 8 nM
1G244
i.e. (2S)-2-amino-4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-1-(1,3-dihydro-2H-isoindol-2-yl)-1,4-butanedione, specific inhibitor of DPP8 and DPP9
additional information
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inhibition by monovalent cations in decreasing order CN-, SCN-, N3-, I-, NO3-, HCO3-, Br-, OAc-, Cl-, F-
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