Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.13.19: membrane dipeptidase

This is an abbreviated version!
For detailed information about membrane dipeptidase, go to the full flat file.

Word Map on EC 3.4.13.19

Reaction

hydrolysis of dipeptides =

Synonyms

43 kDa renal band 3-related protein, aminodipeptidase, dehydropeptidase I (DPH I), DHP-I, dipeptidase, dipeptide hydrolase, dipeptidyl hydrolase, DPP9, EC 3.4.13.11, glycosyl-phosphatidylinositol-anchored renal dipeptidase, GPI-renal dipeptidase, LDP, lysosomal dipeptidase, MBD, MBD-1, MBD-2, MBD-3, MDP, membrane-associated dipeptidase, microsomal MBD, nonspecific dipeptidase, PepD, PepV, RDP, RDPase, renal dipeptidase, Sco3058, Ser-Met dipeptidase, tissue carnosinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.13 Dipeptidases
                3.4.13.19 membrane dipeptidase

Inhibitors

Inhibitors on EC 3.4.13.19 - membrane dipeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-(trifluoromethyl)phenyl)acrylic acid
-
50% inhibition at 10 nM
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-bromophenyl)acrylic acid
-
50% inhibition at 6 nM
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-fluorophenyl)acrylic acid
-
50% inhibition at 5 nM
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-iodophenyl)acrylic acid
-
50% inhibition at 8 nM
1,10-phenanthroline
1G244
i.e. (2S)-2-amino-4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-1-(1,3-dihydro-2H-isoindol-2-yl)-1,4-butanedione, specific inhibitor of DPP8 and DPP9
acetate
-
-
bestatin
Cd2+
-
-
Cilastatin
CN-
-
-
Co2+
-
-
cysteine
-
-
Cystinyl-bis-glycine
-
inhibition above 0.2 mM, substrate below
Dansylethylenediamine
-
cilastatin protects
guanosine triphosphate
-
-
HCO3-
-
-
L-Cys-Gly
-
substrate inhibition
N-bromosuccinimide
-
-
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
-
cilastatin protects
N-ethylmaleimide
-
22% inhibition at 1 mM
Ni2+
-
-
NO3-
-
-
nucleotides
-
-
-
p-hydroxymercuribenzoate
-
-
Phenylmethylsulfonylfluoride
-
41% inhibition at 1 mM
phosphate
-
-
phosphinate mimic of L-Ala-D-Asp
-
-
Pro-Ala
-
competitive to hydrolysis of Gly-Leu
SO42-
-
-
thiol compounds
-
-
Z-2-(2,2-Dimethylcyclopropanecarboxamido)-2-butenoic acid
-
-
additional information
-