3.4.13.19: membrane dipeptidase

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For detailed information about membrane dipeptidase, go to the full flat file.

Reaction

hydrolysis of dipeptides =

Synonyms

43 kDa renal band 3-related protein, aminodipeptidase, dehydropeptidase I (DPH I), DHP-I, dipeptidase, dipeptide hydrolase, dipeptidyl hydrolase, DPP9, EC 3.4.13.11, glycosyl-phosphatidylinositol-anchored renal dipeptidase, GPI-renal dipeptidase, LDP, lysosomal dipeptidase, MBD, MBD-1, MBD-2, MBD-3, MDP, membrane-associated dipeptidase, microsomal MBD, nonspecific dipeptidase, PepD, PepV, RDP, RDPase, renal dipeptidase, Sco3058, Ser-Met dipeptidase, tissue carnosinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.13 Dipeptidases

                3.4.13.19 membrane dipeptidase

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Results	in table
1	Activating Compound
7315	AA Sequence
2	Application
1	CAS Registry Number
10	Cloned(Commentary)
2	Crystallization (Commentary)
87	Disease/ Diagnostics
2	General Information
3	General Stability
67	Inhibitors
28	kcat/KM [mM/s]
1	Ki Value [mM]
49	KM Value [mM]
26	Localization
22	Metals/Ions
35	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
50	Organism
6	Pathway
22	PDB ID
5	pH Optimum
1	pH Range
5	pH Stability
4	pI Value
16	Posttranslational Modification
13	Protein Variants
23	Purification (Commentary)
1	Reaction
1	Reaction Type
50	Reference
1	Renatured (Commentary)
54	Source Tissue
14	Specific Activity [micromol/min/mg]
5	Storage Stability
152	Substrates and Products (Substrate)
15	Subunits
43	Synonyms
4	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
24	Turnover Number [1/s]

Engineering

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Engineering on EC 3.4.13.19 - membrane dipeptidase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

H413K/H417K

Mus musculus

-

catalytic activity reduced to background levels. Animals carrying the mutant enzyme generate 1 embryo from 22 plugged females compared to 153 embryos from 19 females in wild-type. There is no difference in sperm count, morphology or motility after capacitation in mutant animals. While sperm from wild-type males readily binds to the zona pellucida of unfertilized eggs, sperm from homozygous mutant males shows background levels of binding

670357

D22H

Streptomyces coelicolor

-

mutant with no residual enzyme acitvity

707533

D320A

Streptomyces coelicolor

-

mutant with no residual enzyme acitvity

707533

D320N

Streptomyces coelicolor

-

mutant with no residual enzyme acitvity

707533

H150A

Streptomyces coelicolor

-

mutant with more than doubled Km-values

707533

H150N

Streptomyces coelicolor

-

mutant with more than doubled Km-values

707533

R223K

Streptomyces coelicolor

-

mutant with about 3fold reduced activity compared to wild-type enzyme

707533

R223M

Streptomyces coelicolor

-

mutant with no residual enzyme acitvity

707533

H128L

Sus scrofa

-

mutant enzyme exhibits a specific activity and Km for Gly-D-Phe comparable with that of the wild-type enzyme

647114

H152L

Sus scrofa

-

inactive mutant enzyme is expressed at the cell surface at equivalent levels to the wild-type, the mutant enzyme fails to bind to cilastatin-Sepharose in contrast to the wild-type enzyme

647114

H198K

Sus scrofa

-

inactive mutant enzyme is expressed at the cell surface at equivalent levels to the wild-type

647114

H20L

Sus scrofa

-

inactive mutant enzyme is expressed at the cell surface at equivalent levels to the wild-type

647114

H49K

Sus scrofa

-

mutant enzyme exhibits a specific activity and Km for Gly-D-Phe comparable with that of the wild-type enzyme

647114