3.4.13.19: membrane dipeptidase

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For detailed information about membrane dipeptidase, go to the full flat file.

Reaction

hydrolysis of dipeptides =

Synonyms

43 kDa renal band 3-related protein, aminodipeptidase, dehydropeptidase I (DPH I), DHP-I, dipeptidase, dipeptide hydrolase, dipeptidyl hydrolase, DPP9, EC 3.4.13.11, glycosyl-phosphatidylinositol-anchored renal dipeptidase, GPI-renal dipeptidase, LDP, lysosomal dipeptidase, MBD, MBD-1, MBD-2, MBD-3, MDP, membrane-associated dipeptidase, microsomal MBD, nonspecific dipeptidase, PepD, PepV, RDP, RDPase, renal dipeptidase, Sco3058, Ser-Met dipeptidase, tissue carnosinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.13 Dipeptidases

                3.4.13.19 membrane dipeptidase

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Results	in table
1	Activating Compound
7315	AA Sequence
2	Application
1	CAS Registry Number
10	Cloned(Commentary)
2	Crystallization (Commentary)
87	Disease/ Diagnostics
2	General Information
3	General Stability
67	Inhibitors
28	kcat/KM [mM/s]
1	Ki Value [mM]
49	KM Value [mM]
26	Localization
22	Metals/Ions
35	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
50	Organism
6	Pathway
22	PDB ID
5	pH Optimum
1	pH Range
5	pH Stability
4	pI Value
16	Posttranslational Modification
13	Protein Variants
23	Purification (Commentary)
1	Reaction
1	Reaction Type
50	Reference
1	Renatured (Commentary)
54	Source Tissue
14	Specific Activity [micromol/min/mg]
5	Storage Stability
152	Substrates and Products (Substrate)
15	Subunits
43	Synonyms
4	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
24	Turnover Number [1/s]

General Information

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General Information on EC 3.4.13.19 - membrane dipeptidase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Streptomyces coelicolor

-

glutathione metabolism

707533

physiological function

Homo sapiens

Q86TI2

survival and the proliferative capacity are significantly diminished in the presence of 10 microM of inhibitor 1G244, both in fibroblasts and in HaCaT cells. DPP9 gene silencing results in decreased adhesion of fibroblasts, as well as in decreased migration of fibroblasts and HaCaTcells. DPP9 accumulates on the edges of plasma membranes of fibroblasts and keratinocytes adhering to surface

753783