3.4.13.19: membrane dipeptidase

This is an abbreviated version!
For detailed information about membrane dipeptidase, go to the full flat file.

Reaction

hydrolysis of dipeptides =

Synonyms

43 kDa renal band 3-related protein, aminodipeptidase, dehydropeptidase I (DPH I), DHP-I, dipeptidase, dipeptide hydrolase, dipeptidyl hydrolase, DPP9, EC 3.4.13.11, glycosyl-phosphatidylinositol-anchored renal dipeptidase, GPI-renal dipeptidase, LDP, lysosomal dipeptidase, MBD, MBD-1, MBD-2, MBD-3, MDP, membrane-associated dipeptidase, microsomal MBD, nonspecific dipeptidase, PepD, PepV, RDP, RDPase, renal dipeptidase, Sco3058, Ser-Met dipeptidase, tissue carnosinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.13 Dipeptidases

                3.4.13.19 membrane dipeptidase

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Results	in table
1	Activating Compound
7315	AA Sequence
2	Application
1	CAS Registry Number
10	Cloned(Commentary)
2	Crystallization (Commentary)
87	Disease/ Diagnostics
2	General Information
3	General Stability
67	Inhibitors
28	kcat/KM [mM/s]
1	Ki Value [mM]
49	KM Value [mM]
26	Localization
22	Metals/Ions
35	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
50	Organism
6	Pathway
22	PDB ID
5	pH Optimum
1	pH Range
5	pH Stability
4	pI Value
16	Posttranslational Modification
13	Protein Variants
23	Purification (Commentary)
1	Reaction
1	Reaction Type
50	Reference
1	Renatured (Commentary)
54	Source Tissue
14	Specific Activity [micromol/min/mg]
5	Storage Stability
152	Substrates and Products (Substrate)
15	Subunits
43	Synonyms
4	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
24	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 3.4.13.19 - membrane dipeptidase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

20 - 70

Bifidobacterium longum

-

the enzyme shows about 30% and 50% of the maximum activity at 20°C and 70°C, respectively, stable at temperatures up to 70°C, but the activity decreased rapidly above 80°C

677698

40

Homo sapiens

-

enzyme form S is unstable above

647108

53

Homo sapiens

-

12 min, about 50% loss of activity

137177

60

Homo sapiens

-

enzyme form F is stable up to

647108

70

Geobacillus stearothermophilus

-

30 min, about 15% loss of activity of the native enzyme, about 55% of the activity of the Co2+-reconstituted enzyme, about 75% loss of activity of the Mn2+-reconstituted enzyme

647111

additional information

Geobacillus stearothermophilus

-

substitution of Co2+ or Mn2+ for Zn2+ considerably lowers the thermostability of the enzyme without affecting the overall conformation of the protein

647111