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Literature summary for 3.4.13.19 extracted from

  • Fuchs, S.; Frenzel, K.; Hubert, C.; Lyng, R.; Muller, L.; Michaud, A.; Xiao, H.D.; Adams, J.W.; Capecchi, M.R.; Corvol, P.; Shur, B.D.; Bernstein, K.E.
    Male fertility is dependent on dipeptidase activity of testis ACE (2005), Nat. Med., 11, 1140-1142.
    View publication on PubMed
Search for more literature for 3.4.13.19

Application

Application Comment Organism
medicine dicarboxypeptidase activity of testis angiotensin-converting enzyme is required for fertility. Animals carrying mutant enzyme without catalytic activity generate 1 embryo from 22 plugged females compared to 153 embryos from 19 females in wild-type Mus musculus

Protein Variants

Protein Variants Comment Organism
H413K/H417K catalytic activity reduced to background levels. Animals carrying the mutant enzyme generate 1 embryo from 22 plugged females compared to 153 embryos from 19 females in wild-type. There is no difference in sperm count, morphology or motility after capacitation in mutant animals. While sperm from wild-type males readily binds to the zona pellucida of unfertilized eggs, sperm from homozygous mutant males shows background levels of binding Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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 with selective genetic inactivation of the dicarboxypeptidase activity of testis angiotensin-converting enzyme
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Source Tissue

Source Tissue Comment Organism Textmining
testis selective genetic inactivation of the dicarboxypeptidase activity of testis angiotensin-converting enzyme Mus musculus
-