3.1.4.54: N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

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For detailed information about N-acetylphosphatidylethanolamine-hydrolysing phospholipase D, go to the full flat file.

Reaction

Synonyms

anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, N-acyl-phosphatidylethanolamine-specific phospholipase D, N-acylphosphatidylethanolamine-specific phospholipase D, NAPE-hydrolysing phospholipase D, NAPE-PLD, NAPEPLD

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.4 Phosphoric-diester hydrolases

                3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

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Results	in table
21	Activating Compound
726	AA Sequence
4	Application
12	Cloned(Commentary)
1	Crystallization (Commentary)
36	Disease/ Diagnostics
5	Expression
22	General Information
3	General Stability
5	IC50 Value
32	Inhibitors
32	KM Value [mM]
6	Localization
29	Metals/Ions
6	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
321	Organism
3	Pathway
2	PDB ID
10	pH Optimum
3	Posttranslational Modification
38	Protein Variants
6	Purification (Commentary)
1	Reaction
43	Reference
51	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
64	Substrates and Products (Substrate)
6	Subunits
31	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]

IC50 Value

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IC50 Value on EC 3.1.4.54 - N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.01

1,2-dihexanoyl-glycero-N-(3-(tetradecanoylamino)propyl)phosphoramidate

Homo sapiens

Q6IQ20

pH 8.0, 37°C

708110

0.0367 - 0.0892

2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide

3 entries

0.067

4-(4-(2-(3-methoxyphenyl)benzo[b]thiophen-3-yl)phenoxy)-N,N-dimethylethan-1-amine

Homo sapiens

-

pH 7.5, 37°C

749455

0.0367

2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide

Homo sapiens

Q6IQ20

mutant Q320S, pH not specified in the publication, temperature not specified in the publication

750295

0.0462

2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide

Homo sapiens

Q6IQ20

wild-type, pH not specified in the publication, temperature not specified in the publication

750295

0.0892

2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide

Homo sapiens

Q6IQ20

mutant Q320A, pH not specified in the publication, temperature not specified in the publication

750295