Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.1.4.54: N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

This is an abbreviated version!
For detailed information about N-acetylphosphatidylethanolamine-hydrolysing phospholipase D, go to the full flat file.

Word Map on EC 3.1.4.54

Reaction

N-acylphosphatidylethanolamine
+
H2O
=
N-acylethanolamine
 +
a 1,2-diacylglycerol 3-phosphate

Synonyms

anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, N-acyl-phosphatidylethanolamine-specific phospholipase D, N-acylphosphatidylethanolamine-specific phospholipase D, NAPE-hydrolysing phospholipase D, NAPE-PLD, NAPEPLD

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

Inhibitors

Inhibitors on EC 3.1.4.54 - N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-dihexanoyl-glycero-N-(3-(tetradecanoylamino)propyl)phosphoramidate
i.e. AHP-71B, 96.6% inhibition at 1 mM
2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide
reversible uncompetitive inhibitor, compound binds via a reversible mechanism to the enzyme's zinc center. Compound is not inhibitory to carbonic anhydrase II, neutral endopeptidase and angiotensin-converting enzyme
2-arachidonoylglycerol
0.05 mM, 67% loss of activity
4-(4-(2-(3-methoxyphenyl)benzo[b]thiophen-3-yl)phenoxy)-N,N-dimethylethan-1-amine
-
compound additionally inhibits human phospholipases Pld1 and Pld2 and Pseudomonas aeruginosa PldA
4-chloromercuribenzoic acid
-
-
Ca2+
-
-
capsaicin
0.005 mM, 20% inhibition
Cd2+
10 mM, more than 90% inhibition
cetyltrimethylammonium chloride
strongly inhibits the enzyme of all brain regions
EDTA
-
-
methyl arachidonyl fluorophosphonate
above 0.1 mM
N-(2,4-dinitrophenyl)-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine
1 mM, 35.6% inhibition
N-(4-hydroxy-2-methylphenyl)-arachidonoylamide
0.005 mM, 82% inhibition
N-arachidonoylethanolamine
0.05 mM, 37% loss of activity
N-oleoylethanolamine
0.05 mM, 36% loss of activity
N-stearoylethanolamine
0.005 mM, 14% loss of activity
nitrocefin
-
noladin ether
0.005 mM, 70% loss of activity
p-chloromercuribenzoate
-
p-chloromercuribenzoic acid
strongly inhibits the enzyme of all brain regions
phosphatidylhexanol
-
receptor agonist ACEA
0.005 mM, 56% loss of activity
Triton X-100
-
-