3.1.4.54: N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
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For detailed information about N-acetylphosphatidylethanolamine-hydrolysing phospholipase D, go to the full flat file.
Word Map on EC 3.1.4.54
Reaction
Synonyms
anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, N-acyl-phosphatidylethanolamine-specific phospholipase D, N-acylphosphatidylethanolamine-specific phospholipase D, NAPE-hydrolysing phospholipase D, NAPE-PLD, NAPEPLD
ECTree
3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase DAdvanced search results
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results (Expression
Expression on EC 3.1.4.54 - N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
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EXPRESSION 
ORGANISM
UNIPROT
LITERATURE
capsaicin treatment overnight downregulates NAPE-PLD expression in capsaicin-sensitive cells by 70% at 0.01 mM
ethanol downregulates microglial NAPE-PLD expression by activating cAMP/PKA and ERK1/2
Nape-pld is regulated by ovarian steroid hormones via their nuclear receptors
the pro-inflammatory bacterial endotoxin, lipopolysaccharide, decreases palmitoylethanolamide biosynthesis in RAW264.7 macrophages by suppressing the transcription of NAPE-PLD, which catalyzes the production of palmitoylethanolamide and other lipid amides. Liopolysaccharide treatment reduces acetylation of histone proteins bound to the NAPE-PLD promoter, an effect that is blocked by the histone deacetylase inhibitor richostatin A. The transcription factor Sp1 is involved in regulating baseline NAPE-PLD expression, but not in the transcriptional suppression induced by lipopolysaccharide. The down-regulation of NAPE-PLD expression may be functionally important because mutant NAPE-PLD-null mice, in which this regulatory process is defective, are unable to mount a normal inflammatory reaction in response to carrageenan
