3.1.4.54: N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

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For detailed information about N-acetylphosphatidylethanolamine-hydrolysing phospholipase D, go to the full flat file.

Reaction

Synonyms

anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, N-acyl-phosphatidylethanolamine-specific phospholipase D, N-acylphosphatidylethanolamine-specific phospholipase D, NAPE-hydrolysing phospholipase D, NAPE-PLD, NAPEPLD

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.4 Phosphoric-diester hydrolases

                3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

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Results	in table
21	Activating Compound
726	AA Sequence
4	Application
12	Cloned(Commentary)
1	Crystallization (Commentary)
36	Disease/ Diagnostics
5	Expression
22	General Information
3	General Stability
5	IC50 Value
32	Inhibitors
32	KM Value [mM]
6	Localization
29	Metals/Ions
6	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
321	Organism
3	Pathway
2	PDB ID
10	pH Optimum
3	Posttranslational Modification
38	Protein Variants
6	Purification (Commentary)
1	Reaction
43	Reference
51	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
64	Substrates and Products (Substrate)
6	Subunits
31	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]

Disease

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Disease on EC 3.1.4.54 - N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Atherosclerosis

Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation.

30354245

Colitis

A Palmitoylethanolamide Producing Lactobacillus paracasei Improves Clostridium difficile Toxin A-Induced Colitis.

33986673

Endometrial Neoplasms

Expression and Function of the Endocannabinoid Modulating Enzymes Fatty Acid Amide Hydrolase and N-Acylphosphatidylethanolamine-Specific Phospholipase D in Endometrial Carcinoma.

31921630

Endometritis

Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows.

29542183

Hyperalgesia

Antihyperalgesic Activities of Endocannabinoids in a Mouse Model of Antiretroviral-Induced Neuropathic Pain.

28373843

Leukoencephalopathies

Canine NAPEPLD-associated models of human myelin disorders.

29643404

Multiple Sclerosis

Cannabinoid Receptor and N-acyl Phosphatidylethanolamine Phospholipase D - Evidence for Altered Expression in Multiple Sclerosis.

21707818

Neoplasms

Altered mRNA Expression of Genes Involved in Endocannabinoid Signalling in Squamous Cell Carcinoma of the Oral Tongue.

31423851

Neoplasms

Effects of orthotopic implantation of rat prostate tumour cells upon components of the N-acylethanolamine and monoacylglycerol signalling systems: an mRNA study.

32286386

Neoplasms

Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows.

29542183

Neoplasms

Perturbations of the endocannabinoid system in mantle cell lymphoma: correlations to clinical and pathological features.

25594062

Neuralgia

Analgesic effects of FAAH inhibitor in the insular cortex of nerve-injured rats.

30380982

Obesity

A Common Haplotype in NAPEPLD Is Associated With Severe Obesity in a Norwegian Population-Based Cohort (the HUNT Study).

20885390

Obesity, Morbid

A Common Haplotype in NAPEPLD Is Associated With Severe Obesity in a Norwegian Population-Based Cohort (the HUNT Study).

20885390

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