3.1.26.5: ribonuclease P

This is an abbreviated version!
For detailed information about ribonuclease P, go to the full flat file.

Reaction

endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor =

Synonyms

Aq_880, aRpp29, aRpp29 protein, AtPop1p, AtPRORP1, AtPRORP2, AtPRORP3, C5 protein, CrPRORP, hPOP1, hPOP4, hPOP7, M1 RNA, M1GS, M1GS RNA, mitochondrial RNase P protein 1, MRPP1, MRPP2, MRPP3, nuclear ribonclease P ribonucleoprotein, nuclease, ribo-, P, Pfu Pop5, PhoPRNA, POP1, Pop1p, Pop5, Pop6, Pop7, PRORP, PRORP1, PRORP2, PRORP3, Protein C5, protein-only ribonuclease P, protein-only RNase P, protein-only RNase P enzyme, proteinaceous RNase P, ribonuclease MRP, ribonuclease P, ribonuclease P ribozyme, ribosomal RNA processing ribonucleoprotein, Ribunuclease P, RNA processing protein POP1, RNA processing protein POP5, RNA processing protein POP6, RNA processing protein POP7, RNA processing protein POP8, RNase MRP, RNase P, RNase P holoenzyme, RNase P protein, RNase P ribozyme, RNase P RNA, RNase P/MRP, RNase P/MRP protein, RNaseP protein, RNaseP protein p20, RNaseP protein p30, RNaseP protein p38, RNaseP protein p40, RNases P, RNP, Rpm2p, RPP, RPP14, Rpp20, Rpp21, Rpp25, Rpp29, Rpp30, Rpp38, RPP40, RPR, RPR1, transfer RNA 5' maturation enzyme, transfer RNA processing enzyme, tRNA processing enzyme, tRNA-processing endonuclease, tRNA-processing enzyme

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.26 Endoribonucleases producing 5'-phosphomonoesters

                3.1.26.5 ribonuclease P

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Results	in table
21	Activating Compound
43918	AA Sequence
25	Application
1	CAS Registry Number
65	Cloned(Commentary)
2	Cofactor
21	Crystallization (Commentary)
353	Disease/ Diagnostics
5	Expression
163	General Information
6	General Stability
5	IC50 Value
89	Inhibitors
23	kcat/KM [mM/s]
18	Ki Value [mM]
59	KM Value [mM]
130	Localization
229	Metals/Ions
94	Molecular Weight [Da]
129	Natural Substrates/ Products (Substrates)
1063	Organism
1	Pathway
185	PDB ID
53	pH Optimum
4	pH Range
15	pI Value
103	Posttranslational Modification
146	Protein Variants
88	Purification (Commentary)
35	Reaction
2	Reaction Type
488	Reference
4	Renatured (Commentary)
29	Source Tissue
5	Specific Activity [micromol/min/mg]
2	Storage Stability
531	Substrates and Products (Substrate)
96	Subunits
526	Synonyms
57	Temperature Optimum [°C]
6	Temperature Range [°C]
5	Temperature Stability [°C]
37	Turnover Number [1/s]

Expression

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Expression on EC 3.1.26.5 - ribonuclease P

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

down-regulation of a single RNase P protein in cultured human cells results in a concomitant decrease of up to four other RNase P proteins (but not the RNase P RNA), likely due to transcriptional repression

Homo sapiens

-

708512

RNase P RNA expression decreases during the stringent response induced by amino acid starvation/cis-acting sequences in the RNase P RNA promoter

Escherichia coli

-

709542

RNase P-external guide sequence and short hairpin RNAi technologies have about equal levels of inhibition of RNase P protein subunits

Homo sapiens

-

710127

Salmonella RNase P-based ribozyme sequence delivered in specific human cells, leads to substantial ribozyme expression. The M1GS RNAs appears to be exclusively expressed in the nuclei

synthetic construct

-

710437

when plasmids carrying the M1GS constructs are delivered to murine cytomegalovirus-infected mice by a hydrodynamic transfection procedure, the M1GS RNA is expressed in a substantial amount in the livers and spleens of the animals

Escherichia coli

-

710127