3.1.26.5: ribonuclease P
This is an abbreviated version!
For detailed information about ribonuclease P, go to the full flat file.
Word Map on EC 3.1.26.5
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3.1.26.5
-
ribonucleoproteins
-
pre-trnas
-
endoribonuclease
-
endonucleolytic
-
eculizumab
-
aminoacylation
-
rna-based
-
stem-loops
-
phosphodiester
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nucleolar
-
nocturnal
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eubacterial
-
paroxysmal
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gene-targeting
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anticodon
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base-pairing
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rna-protein
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sars-cov-2
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c5a
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horikoshii
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hemoglobinuria
-
trna-like
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pyrococcus
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swab
-
3'-terminal
-
5\'-leader
-
riboswitches
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trnatyr
-
2'-hydroxyls
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trnahis
-
trailer
-
cloverleaf
-
rna-rna
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self-splicing
-
protein-rna
-
tmrna
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micrococcal
-
self-cleaving
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t-loops
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p-mediated
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complement-mediated
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ncrnas
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pseudoknots
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watson-crick
-
eukaryal
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oligoribonucleotides
-
analysis
-
pharmacology
-
snornps
-
synthesis
-
medicine
-
biotechnology
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trnase
- 3.1.26.5
- ribonucleoproteins
- pre-trnas
-
endoribonuclease
-
endonucleolytic
- eculizumab
- aminoacylation
-
rna-based
-
stem-loops
-
phosphodiester
-
nucleolar
-
nocturnal
-
eubacterial
-
paroxysmal
-
gene-targeting
-
anticodon
-
base-pairing
-
rna-protein
- sars-cov-2
- c5a
- horikoshii
- hemoglobinuria
-
trna-like
- pyrococcus
-
swab
-
3'-terminal
-
5\'-leader
- riboswitches
- trnatyr
-
2'-hydroxyls
- trnahis
- trailer
-
cloverleaf
-
rna-rna
-
self-splicing
-
protein-rna
- tmrna
-
micrococcal
-
self-cleaving
-
t-loops
-
p-mediated
-
complement-mediated
- ncrnas
-
pseudoknots
-
watson-crick
-
eukaryal
- oligoribonucleotides
- analysis
- pharmacology
-
snornps
- synthesis
- medicine
- biotechnology
-
trnase
Reaction
endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor =
Synonyms
Aq_880, aRpp29, aRpp29 protein, AtPop1p, AtPRORP1, AtPRORP2, AtPRORP3, C5 protein, CrPRORP, hPOP1, hPOP4, hPOP7, M1 RNA, M1GS, M1GS RNA, mitochondrial RNase P protein 1, MRPP1, MRPP2, MRPP3, nuclear ribonclease P ribonucleoprotein, nuclease, ribo-, P, Pfu Pop5, PhoPRNA, POP1, Pop1p, Pop5, Pop6, Pop7, PRORP, PRORP1, PRORP2, PRORP3, Protein C5, protein-only ribonuclease P, protein-only RNase P, protein-only RNase P enzyme, proteinaceous RNase P, ribonuclease MRP, ribonuclease P, ribonuclease P ribozyme, ribosomal RNA processing ribonucleoprotein, Ribunuclease P, RNA processing protein POP1, RNA processing protein POP5, RNA processing protein POP6, RNA processing protein POP7, RNA processing protein POP8, RNase MRP, RNase P, RNase P holoenzyme, RNase P protein, RNase P ribozyme, RNase P RNA, RNase P/MRP, RNase P/MRP protein, RNaseP protein, RNaseP protein p20, RNaseP protein p30, RNaseP protein p38, RNaseP protein p40, RNases P, RNP, Rpm2p, RPP, RPP14, Rpp20, Rpp21, Rpp25, Rpp29, Rpp30, Rpp38, RPP40, RPR, RPR1, transfer RNA 5' maturation enzyme, transfer RNA processing enzyme, tRNA processing enzyme, tRNA-processing endonuclease, tRNA-processing enzyme
ECTree
3.1.26.5 ribonuclease PAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.1.26.5 - ribonuclease P
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4.5S RNA precursor + H2O
mature 4.5S RNA + 5'-oligonucleotide
-
RNA processing
-
-
?
pre-tRNA + H2O
?
-
ribonucleoprotein enzyme required for 5'-end maturation of precursor tRNAs (pre-tRNAs)
-
-
?
precursor tRNA + H2O
77- and 35-RNA fragments
-
ribonuclease P is the endonuclease that removes the leader fragments from the 5'-ends of precursor tRNAs
-
-
?
tmRNA precursor + H2O
mature tmRNA + 5'-oligonucleotide
-
RNA processing
-
-
?
tRNA-like pseudoknotted structures in viral RNA + H2O
processed RNA + ?
-
tRNA-like pseudoknotted structures in viral RNA
-
-
?
pre-rRNA + H2O
mature rRNA
-
enzyme RNase MRP plays an important role in pre-rRNA processing
-
-
?
pre-rRNA + H2O
mature rRNA
-
enzyme RNase MRP plays an important role in pre-rRNA processing
-
-
?
pre-tRNA + H2O
mature tRNA + 5'-terminal oligonucleotide
-
-
-
?
pre-tRNA + H2O
mature tRNA + 5'-terminal oligonucleotide
the enzyme is involved in maturation of the 5'-end of tRNA
-
-
?
pre-tRNA + H2O
tRNA
-
Ribonuclease P (RNase P) is a ribozyme that is responsible for thematuration of 5' termini of tRNA molecules
-
-
?
pre-tRNA + H2O
tRNA + 5'-oligoribonucleotide
-
the enzyme is responsible for the cleavage of sequences from the 5' ends of precursors of tRNAs to produce the mature 5' terminus of the tRNA molecules
-
-
?
pre-tRNA + H2O
tRNA + 5'-oligoribonucleotide
Chlamydomonas reinhardtii cw15 arg7-8 mt+
-
-
-
-
?
pre-tRNA + H2O
tRNA + 5'-oligoribonucleotide
-
in addition to its essential role in the biosynthesis of tRNA, RNase P may have another function in vivo, namely, in the physiology of viral infections
-
-
?
pre-tRNA + H2O
tRNA + 5'-oligoribonucleotide
-
the enzyme is responsible for the cleavage of sequences from the 5' ends of precursors of tRNAs to produce the mature 5' terminus of the tRNA molecules
-
-
?
pre-tRNA + H2O
tRNA + 5'-oligoribonucleotide
-
autoantigenic properties of the protein subunits Rpp38 and Rpp30 of catalytically active complexes of human ribonuclease P
-
-
?
pre-tRNA + H2O
tRNA + 5'-oligoribonucleotide
-
involved in biosynthesis of KB cell tRNA
-
-
?
pre-tRNA + H2O
tRNA + 5'-oligoribonucleotide
the enzyme is involved in maturation of the 5'-end of tRNA
-
-
?
pre-tRNA + H2O
tRNA + 5'-oligoribonucleotide
-
removal of a 5' leader sequence from tRNA precursor
-
-
?
pre-tRNA + H2O
tRNA + 5'-oligoribonucleotide
-
the enzyme is responsible for the cleavage of sequences from the 5' ends of precursors of tRNAs to produce the mature 5' terminus of the tRNA molecules
-
-
?
precursor tRNA + H2O
?
-
catalyze the 5' maturation of precursor tRNA
-
-
?
precursor tRNA + H2O
?
-
RNase P is an endoribonuclease responsible for generating the 5' end of mature tRNA molecules and, in bacteria, this ribonucleoprotein complex consists of a basic protein and an RNA moiety in a 1:1 ratio
-
-
?
precursor tRNA + H2O
?
-
catalyzes the magnesium-dependent 5'-end maturation of tRNAs
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation, essential
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation, essential
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
essential enzymes in the biogenesis of tRNA, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
tRNA processing
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation, essential
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
essential enzymes in the biogenesis of tRNA, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation, essential
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
essential enzymes in the biogenesis of tRNA, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
tRNA processing
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
5'-leader sequence tRNA processing, essential enzyme
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation, essential
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
essential enzymes in the biogenesis of tRNA, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation, essential
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
essential enzymes in the biogenesis of tRNA, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation, essential
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
essential enzymes in the biogenesis of tRNA, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
tRNA processing
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
tRNA processing
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation, essential
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
essential enzymes in the biogenesis of tRNA, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
tRNA processing, the premature substrate is associated with a complex of 7 Sm-like proteins, i.e. Lsm2-8, and U6 snRNA
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
essential enzymes in the biogenesis of tRNA, maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
tRNA processing
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation, essential
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-oligonucleotide
-
cleavage of 5'-terminal oligonucleotide, maturation, essential
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-terminal oligonucleotide
-
enzyme is responsible for removing the 5'-leader segment of precursor tRNA during maturation
-
-
?
tRNA precursor + H2O
mature tRNA + 5'-terminal oligonucleotide
-
enzyme is responsible for removing the 5'-leader segment of precursor tRNA
-
-
?
additional information
?
-
-
5'-endonucleolytic precursor tRNA cleavage
-
-
?
additional information
?
-
L0N807
the enzyme processes the 5'-end of tRNAs
-
-
?
additional information
?
-
the natural substrate is precursor tRNA
-
-
?
additional information
?
-
-
the natural substrate is precursor tRNA
-
-
?
additional information
?
-
-
other pre-RNAs are also physiological substrates of the enzyme
-
-
?
additional information
?
-
-
substrate specificity is determined by the enzymes' RNA fold, the structure of the specificity domain of the RNA subunit provides the basis of understanding the structurs of other bacterial ribozyme molecules because all bacterial S domains havea common core that comprises stems P7-P11 plus J11/12-J12/11 module, overview
-
-
?
additional information
?
-
-
catalyzes the 5-end maturation of tRNAs in all Kingdoms of life
-
-
?
additional information
?
-
-
5'-endonucleolytic precursor tRNA cleavage
-
-
?
additional information
?
-
-
ribonuclease P catalyzes the metal-dependent 5' end maturation of precursor tRNAs
-
-
?
additional information
?
-
-
the enzyme catalyzes the 5' end maturation of precursor tRNAs (pre-tRNAs)
-
-
?
additional information
?
-
-
other pre-RNAs are also physiological substrates of the enzyme
-
-
?
additional information
?
-
-
catalyses the 5'-end processing reaction of tRNA precursor molecules
-
-
?
additional information
?
-
-
essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs
-
-
?
additional information
?
-
-
5'-endonucleolytic precursor tRNA cleavage
-
-
?
additional information
?
-
-
precursor tRNAs are natural enzyme RNase P substrates
-
-
?
additional information
?
-
-
the enzyme processes the 5' ends of tRNA precursors, the substrate population includes over 80 different competing ptRNAs in Escherichia coli, sequence and secondary structure of representative ptRNAs, overview. Its mode of molecular recognition differs from other catalytic RNAs in two important ways. First, its biological role in ptRNA processing requires that it act in trans as a multiple turnover enzyme, whereas other ribozymes, with the exceptions of the ribosome and spliceosome, undergo single turnover self-splicing or self-cleavage reactions. Second, RNase P processes multiple RNA substrates, including all ptRNAs in the cell, whereas other ribozymes, again with the exceptions of the ribosome and spliceosome, have one specific substrate
-
-
?
additional information
?
-
-
the mechanism by which the enzyme processes the valU and lysT polycistronic transcripts (valV valW, valU valX, valY lysY and lysT valT lysW valZ lysY lysZ lysQ) involves initiation of processing by first endonucleolytically removing the Rho-independent transcription terminators from the primary valU and lysT transcripts. Subsequently, the enzyme proceeds in the 3' -> 5' direction generating one pre-tRNA at a time. Identification of cleavage sites using RNA circularization, overview
-
-
?
additional information
?
-
-
the mechanism by which the enzyme processes the valU and lysT polycistronic transcripts (valV valW, valU valX, valY lysY and lysT valT lysW valZ lysY lysZ lysQ) involves initiation of processing by first endonucleolytically removing the Rho-independent transcription terminators from the primary valU and lysT transcripts. Subsequently, the enzyme proceeds in the 3' -> 5' direction generating one pre-tRNA at a time. Identification of cleavage sites using RNA circularization, overview
-
-
?
additional information
?
-
-
biosynthesis and regulation of RNase P, transient interactions with several proteins in the cell, the protein subunits are conserved between RNase P and RNase MRP, and are essential for cell viability and enzyme function, overview, enzyme subunits in nucleolus and Cajal bodies might be involved in cell mitosis and cell-cycle-dependent gene transcription
-
-
?
additional information
?
-
-
the human mitochondrial RNase P is an entirely protein-based enzyme, protein MRPP1, a probable tRNA methylase, provides tRNA-binding specificity to the RNase P enzyme, protein MRPP2 binds tightly to MRPP1 and is a member of the short chain dehydrogenase/reductase protein family, protein MRPP3 may provide the enzymatic cleavage activity for the patchwork enzyme
-
-
?
additional information
?
-
-
phylogenetic study of archeal enzymes
-
-
?
additional information
?
-
-
5-maturation of transfer RNA
-
-
?
additional information
?
-
-
phylogenetic study of archeal enzymes
-
-
?
additional information
?
-
-
5-maturation of transfer RNA
-
-
?
additional information
?
-
-
the natural substrate is precursor tRNA
-
-
?
additional information
?
-
-
essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs
-
-
?
additional information
?
-
-
the enzyme is a ribonuleoprotein that catalyzes the processing of 5' leader sequences from tRNA precursors and other noncoding RNA
-
-
?
additional information
?
-
-
coordination of RNA pathways, overview
-
-
?
additional information
?
-
-
the mitochondrial ribozyme RNA subunit might have a cellular function outside the mitochondria
-
-
?
additional information
?
-
-
transient interactions with several proteins in the cell, e.g. protein subunit Rpp20 interacts with the heat shock protein Hsp27, protein subunit Rpp14 interacts with several proteins including the LIM domain protein 1 LIMD1 and the SR-rich HSPC232
-
-
?
additional information
?
-
-
involved in regulation of noncoding RNA (ncRNA) expression
-
-
?
additional information
?
-
-
the natural substrate is precursor tRNA
-
-
?
additional information
?
-
the enzyme is an RNA-based enzyme primarily catalyzing 5'-end pre-tRNA processing
-
-
?
additional information
?
-
-
the enzyme is an RNA-based enzyme primarily catalyzing 5'-end pre-tRNA processing
-
-
?
additional information
?
-
-
the natural substrate is precursor tRNA
-
-
?
additional information
?
-
-
essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs
-
-
?
additional information
?
-
-
5'-endonucleolytic precursor tRNA cleavage
-
-
?
additional information
?
-
-
the enzyme processes the 5'-end of tRNAs
-
-
?
additional information
?
-
-
regulation of gene expression can be achieved by creating a complex made of target mRNA and a complementary small oligonucleotide that resembels natural enzyme substrate
-
-
?
additional information
?
-
-
RNase P is the endonuclease that removes 5' extensions from tRNA precursors
-
-
?
additional information
?
-
-
the natural substrate is precursor tRNA. Proteinaceous PRORP1 catalyzes all of the other noncanonical, yet vital functions of nuclear yeast RNase P, which may include processing of non-canonical RNAs
-
-
?
