3.1.21.9: T4 deoxyribonuclease IV

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For detailed information about T4 deoxyribonuclease IV, go to the full flat file.

Reaction

endonucleolytic cleavage of the 5' phosphodiester bond of deoxycytidine in single-stranded DNA =

Synonyms

bacteriophage-T4-induced endonuclease IV, denB, EndoIV, endonuclease IV, T4 endonuclease IV

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters

3.1.21.9 T4 deoxyribonuclease IV

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Results	in table
1	Activating Compound
6	AA Sequence
1	Cloned(Commentary)
2	General Information
7	Inhibitors
3	kcat/KM [mM/s]
22	KM Value [mM]
7	Metals/Ions
3	Natural Substrates/ Products (Substrates)
8	Organism
4	pH Optimum
2	pH Range
3	Purification (Commentary)
1	Reaction
8	Reference
1	Specific Activity [micromol/min/mg]
32	Substrates and Products (Substrate)
6	Synonyms
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.1.21.9 - T4 deoxyribonuclease IV

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DNA + H2O

Tequatrovirus T4

the phage T4 enzyme is involved in degradation of host DNA

134240

DNA where cytosine is partially or completely replaced by hydroxymethylcytosine + H2O

Tequatrovirus T4

DNA where cytosine is partially or completely replaced by hydroxymethylcytosine is degraded in vivo by T4 endonuclease II, EC 3.1.21.8, and endonuclease IV, EC 3.1.21.9

727596

additional information

Tequatrovirus T4

enzyme is capable of cleaving at the atypical apurinic-apyrimidinic site created by the action of T4 PD-DNA glycosylase. Exonuclease III and endonuclease IV are equally efficient in repair

727716