3.1.21.3: type I site-specific deoxyribonuclease

This is an abbreviated version!
For detailed information about type I site-specific deoxyribonuclease, go to the full flat file.

Reaction

endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolysed =

Synonyms

adenosine triphosphate-dependent deoxyribonuclease, ATP-dependent deoxyribonuclease, ATP-dependent DNase, BsaHI restriction-modification system, C.PvuII, CfrAI, deoxyribonuclease (ATP- and S-adenosyl-L-methionine dependent), deoxyribonuclease (ATP-dependent), DNase, EC 3.1.23, EC 3.1.24, EC 3.1.4.33, Eco377I, Eco394I, Eco585I, Eco646I, Eco777I, Eco826I, Eco851I, Eco912I, EcoA0ORF42P, EcoAI, EcoAO83I, EcoB, EcoBI, EcoDI, EcoDXXI, EcoEI, EcoGIV, EcoK, EcoKI, EcoKI type I DNA restriction enzyme, EcoKI type I restriction-modification system, EcoprrI, EcoR, EcoR124, EcoR124/3I, EcoR124I, EcoR124II, EcoRII modification enzyme, EcoRII RM gene complex, EcoRII system, endodeoxyribonuclease, Esp1396I, exodeoxyribonuclease, H91_orf206, H91_orf376, HpyAXII restriction-modification system, HsdM, HsdR, hsdS, KpnBI, More, MpnORFDAP, MpnORFDBP, nuclease, deoxyribo-, nuclease, deoxyribo-, ATP-dependent, PspGI endonuclease, PspGI restriction-modification system, R. BsaHI, R.EcoAI, R.EcoEI, R.EcoKI, R.EcoR124I restriction endonuclease, R.EcoR124II, R.EcoR124INT, R.HpyAXII, R.PspGI, REase, RecoK, restriction-modification system, Sau1, Sau1 type I restriction-modification system, Sau1 Type I RM system, SauMW2I, SauMW2II, SauN315I, SauN315II, StyLTIII, StySBI, StySEAI, StySGI, StySJI, StySKI, StySPI, StySQI, type I R-M enzyme, type I R-M system, type I restriction enzyme, type I restriction modification enzyme, type I restriction-modification enzyme, type I restriction-modification system, type I restriction-modification system EcoR124I, type IB restriction enzyme, type II R-M system, type II restriction-modification system

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters

                3.1.21.3 type I site-specific deoxyribonuclease

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Results	in table
7	Activating Compound
36239	AA Sequence
5	Application
1	CAS Registry Number
27	Cloned(Commentary)
19	Cofactor
10	Crystallization (Commentary)
5	General Information
7	Inhibitors
2	KM Value [mM]
3	Localization
8	Metals/Ions
22	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
71	Organism
27	PDB ID
2	pH Optimum
1	Posttranslational Modification
28	Protein Variants
23	Purification (Commentary)
3	Reaction
1	Reaction Type
66	Reference
68	Substrates and Products (Substrate)
16	Subunits
181	Synonyms
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

General Information

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General Information on EC 3.1.21.3 - type I site-specific deoxyribonuclease

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Staphylococcus aureus

-

Staphylococcus aureus displays a clonal population structure in which horizontal gene transfer between different lineages is extremely rare. This is due, in part, to the presence of a Type I DNA restriction-modification (RM) system given the generic name of Sau1, which maintains different patterns of methylation on specific target sequences on the genomes of different lineages. The determination of so many recognition sequences of Type I RM systems in different lineages of Staphylococcus aureus, means that now the population structure of Staphylococcus aureus can be investigated from an epigenetic/evolutionary perspective

751739

physiological function

4 entries

physiological function

Escherichia coli

-

EcoprrI is an apoptosis enzyme

730505

physiological function

Enterococcus faecium

-

a type I restriction-modification system that is clade A1 specific, is active for DNA methylation, and significantly reduces the transformability of clade A1 Enterococcus faecium. The restriction-modification systems act as barriers to horizontal gene exchange in Enterococcus faecium and contribute to Enterococcus faecium subspecies separation

749678

physiological function

Escherichia coli K-12

P08956; P08957; P05719

the EcoKI type I restriction-modification system in Escherichia coli affects the uptake of DNA by conjugation but is not a major barrier to plasmid transfer

750960

physiological function

Streptococcus suis

-

the type I restriction-modification system hsdS contributes to the Streptococcus suis serotype 2 survival ability in phagocytes. HsdS facilities anti-phagocytosis and survival in microglia and whole blood through positively impacting the expression of virulence-associated factors lysM and lysM', enhancing the survival ability against peroxidation environment, and reducing the TNF-alpha and NO production in microglia

750631