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3.1.13.1: exoribonuclease II

This is an abbreviated version!
For detailed information about exoribonuclease II, go to the full flat file.

Word Map on EC 3.1.13.1

Reaction

Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates =

Synonyms

3'-5'exoribonuclease, 3’-5’exoribonuclease, 5'->3' exoribonuclease 2, AB205_0003320, Dis, Dis3, EC 3.1.4.20, exonuclease ISG20, More, PfRNase II, RC-RNase 2, ribonuclease 2, ribonuclease II, ribonuclease Q, Ribonuclease R, RNase, RNase 2, RNase A, RNase II, RNase R, RNase-2, RNaseR, Rnb, RNR, RNR1, Rrp44, XRN2

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.13 Exoribonucleases producing 5′-phosphomonoesters
                3.1.13.1 exoribonuclease II

Inhibitors

Inhibitors on EC 3.1.13.1 - exoribonuclease II

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5'-capped mRNA
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DNA oligonucleotide with strong duplex structure and 3' single strand
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-
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DNA oligonucleotide with strong duplex structure and 5' single strand
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DNA oligonucleotide with strong duplex structure, 3' and 5' single strand
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DNA oligonucleotide with weak duplex structure and 3' single strand
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DNA oligonucleotide with weak duplex structure and 5' single strand
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-
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DNA oligonucleotide with weak duplex structure, 3' and 5' single strand
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-
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DNA stem-loop structure
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free 3'- and 5'-arms needed for potent inhibition, weaker stem-loops are better inhibitors than their counterpart with a strong duplex
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ds plasmid DNA
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-
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mixed RNA-DNA oligonucleotides
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-
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monovalent or divalent cations
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Na+
-
substrate: artificial polynucleotides
NaCl
-
a salt concentration of 0.05 M inhibits 50% of the activity, salt optimum: 0.01 M
nicotinamide
NAM
oligonucleotides
-
competitive inhibition, fragments bind without being destroyed; small to medium sized
p-chloromercuribenzoate
-
-
poly(A) binding protein
-
inhibits degradation of poly(A)+-strands
-
poly(dC)
-
19 to 29 monomer units chain lenght
Poly(U)
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strong competitive inhibitor of T4 mRNA-degradation
RNA stem-loop structure
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built by repetitive extragenic palindromic sequences; the lower the stability of the RNA-stem, the faster the degradation
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RNA with a 2',3'-cyclic phosphate group
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on the potential substrate molecule
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RNA with a terminal 3'-phosphate group
Rna with a terminal 5'-phosphate group
-
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rRNA
-
weak inhibitor of T4 mRNA-degradation
SDS
-
complete inhibition 10 s after addition of SDS
spermine
-
slight inhibition of poly(U)-degradation
ss DNA oligonucleotides
-
sucrose
-
slight inhibition, in 1% and 5% sucrose 5% and 20% of the activity inhibited
thymidine nucleotides
-
potent inhibitor, pTp at a concentration of 0.00004 M inhibits degradation of poly(A) by 60%, pTpT at a concentration of 0.0005 M inhibits degradation of poly(A) by 30%
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trichostatin A
TSA
Zn2+
-
competitive inhibitor
additional information
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