2.7.1.113: deoxyguanosine kinase

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For detailed information about deoxyguanosine kinase, go to the full flat file.

Word Map on EC 2.7.1.113

2.7.1.113

deoxycytidine

mtdna

thymidine

hepatocerebral

deoxyribonucleoside

deoxynucleoside

ophthalmoplegia

sucla2

twinkle

9-beta-d-arabinofuranosylguanine

cladribine

c10orf2

nystagmus

2-chlorodeoxyadenosine

deoxyinosine

2.7.1.74

2-chloro-2'-deoxyadenosine

mngie

neurogastrointestinal

medicine

Reaction

Synonyms

(dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, deoxyadenosine kinase/deoxyguanosine kinase, deoxyguanosine kinase, DG kinase, DGK, dGKase, DGUOK, kinase, deoxyguanosine (phosphorylating), NTP-deoxyguanosine 5'-phosphotransferase, nucleoside triphosphate: deoxyguanosine 5'-phosphotransferase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.113 deoxyguanosine kinase

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Results	in table
15	Activating Compound
771	AA Sequence
2	Application
1	CAS Registry Number
14	Cloned(Commentary)
33	Cofactor
2	Crystallization (Commentary)
334	Disease/ Diagnostics
2	Expression
9	General Information
9	General Stability
95	Inhibitors
5	kcat/KM [mM/s]
36	Ki Value [mM]
99	KM Value [mM]
32	Localization
47	Metals/Ions
13	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
59	Organism
5	Pathway
18	PDB ID
15	pH Optimum
5	pH Range
3	pH Stability
2	pI Value
42	Protein Variants
9	Purification (Commentary)
5	Reaction
1	Reaction Type
54	Reference
69	Source Tissue
19	Specific Activity [micromol/min/mg]
6	Storage Stability
175	Substrates and Products (Substrate)
8	Subunits
43	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
23	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 2.7.1.113 - deoxyguanosine kinase

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0.0000032

CEM lymphocytes

0.0000338

0.0000635

differentiated adipocytes

0.0007

0.007

purified recombinant enzyme, substrates deoxyguanosine and ATP

0.0103

0.023

substrate 2'-deoxyguanosine and ATP

662985

0.028

Homo sapiens

using 9-beta-D-arabinofuranosylguanine as substrate, in the presence of 1 mM deoxycytidine, in 50 mM Tris-HCl (pH 7.6) containing 5 mM ATP, 4 mM dithiothreitol, 10 mM sodium fluoride and 5 mM MgCl2

671919

0.04 - 0.05

Homo sapiens

recombinant mitochondrial deoxyguanosine kinase

640555

0.058

Homo sapiens

using deoxyguanosine as substrate, in the presence of 1 mM deoxycytidine, in 50 mM Tris-HCl (pH 7.6) containing 5 mM ATP, 4 mM dithiothreitol, 10 mM sodium fluoride and 5 mM MgCl2

671919

0.073

Homo sapiens

using 2-chlorodeoxyadenosine as substrate, in the presence of 1 mM deoxycytidine, in 50 mM Tris-HCl (pH 7.6) containing 5 mM ATP, 4 mM dithiothreitol, 10 mM sodium fluoride and 5 mM MgCl2

671919

0.54

Bacillus subtilis

enzyme in crude recombinant Escherichia coli cell extract, substrate 2'-deoxyguanosine

640561

0.8

Bacillus subtilis

P37530

crude enzyme, at pH and °C

737913

2.3

Bacillus subtilis

dAdo/dCyd kinase in crude recombinant Escherichia coli cell extract, substrate 2'-deoxyadenosine or 2'-deoxycytidine

640561

8.1

2 entries

additional information

3 entries