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Literature summary for 2.7.1.113 extracted from

  • Lotfi, K.; Karlsson, K.; Fyrberg, A.; Juliusson, G.; Jonsson, V.; Peterson, C.; Eriksson, S.; Albertioni, F.
    The pattern of deoxycytidine- and deoxyguanosine kinase activity in relation to messenger RNA expression in blood cells from untreated patients with B-cell chronic lymphocytic leukemia (2006), Biochem. Pharmacol., 71, 882-890.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell
-
Homo sapiens
-
leukemia cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.028
-
using 9-beta-D-arabinofuranosylguanine as substrate, in the presence of 1 mM deoxycytidine, in 50 mM Tris-HCl (pH 7.6) containing 5 mM ATP, 4 mM dithiothreitol, 10 mM sodium fluoride and 5 mM MgCl2 Homo sapiens
0.058
-
using deoxyguanosine as substrate, in the presence of 1 mM deoxycytidine, in 50 mM Tris-HCl (pH 7.6) containing 5 mM ATP, 4 mM dithiothreitol, 10 mM sodium fluoride and 5 mM MgCl2 Homo sapiens
0.073
-
using 2-chlorodeoxyadenosine as substrate, in the presence of 1 mM deoxycytidine, in 50 mM Tris-HCl (pH 7.6) containing 5 mM ATP, 4 mM dithiothreitol, 10 mM sodium fluoride and 5 mM MgCl2 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-chlorodeoxyadenosine
-
Homo sapiens ADP + 2-chlorodeoxyadenosine 5'-monophosphate
-
?
ATP + 2-fluoroadenine-beta-D-arabinofuranoside
-
Homo sapiens ADP + 2-fluoroadenine-beta-D-arabinofuranoside 5'-monophosphate
-
?
ATP + 9-beta-D-arabinofuranosylguanine
-
Homo sapiens ADP + 9-beta-D-arabinofuranosylguanine 5'-monophosphate
-
?
ATP + cytarabine
-
Homo sapiens ADP + cytarabine 5'-monophosphate
-
?
ATP + deoxycytidine
-
Homo sapiens ADP + dCMP
-
?
ATP + deoxyguanosine
-
Homo sapiens ADP + dGMP
-
?

Synonyms

Synonyms Comment Organism
DGK
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens