Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.113 extracted from

  • Sjoberg, A.H.; Wang, L.; Eriksson, S.
    Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs (1998), Mol. Pharmacol., 53, 270-273.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
deoxyguanosine pH 7.6, recombinant mitochondrial deoxyguanosine kinase Homo sapiens
0.012
-
deoxyinosine pH 7.6, recombinant mitochondrial deoxyguanosine kinase Homo sapiens
0.033
-
arabinosyl guanine pH 7.6, recombinant mitochondrial deoxyguanosine kinase Homo sapiens
0.056
-
2-chloro-2'-arabino-fluoro-2'-deoxyadenosine pH 7.6, recombinant mitochondrial deoxyguanosine kinase Homo sapiens
0.078
-
2-chloro-2'-deoxyadenosine pH 7.6, recombinant mitochondrial deoxyguanosine kinase Homo sapiens
0.34
-
deoxycytidine pH 7.6, recombinant mitochondrial deoxyguanosine kinase Homo sapiens
0.46
-
2-fluoro-arabinosyl-adenine pH 7.6, recombinant mitochondrial deoxyguanosine kinase Homo sapiens
0.47
-
deoxyadenosine pH 7.6, recombinant mitochondrial deoxyguanosine kinase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + deoxyinosine Homo sapiens recombinant mitochondrial deoxyguanosine kinase, may be the preferred substrate in vivo ADP + dIMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme, metal affinity chromatography Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.04 0.05 recombinant mitochondrial deoxyguanosine kinase Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine recombinant mitochondrial deoxyguanosine kinase Homo sapiens ADP + 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine 5'-monophosphate
-
?
ATP + 2-chloro-2'-deoxyadenosine recombinant mitochondrial deoxyguanosine kinase Homo sapiens ADP + 2-chloro-2'-deoxyadenosine monophosphate
-
?
ATP + 2-fluoro-arabinosyl-adenine recombinant mitochondrial deoxyguanosine kinase Homo sapiens ADP + 2-fluoro-arabinosyl-adenine 5'-monophosphate
-
?
ATP + arabinosyl adenine recombinant mitochondrial deoxyguanosine kinase, very low activity Homo sapiens ADP + arabinosyl adenine 5'-monophosphate
-
?
ATP + arabinosyl guanine recombinant mitochondrial deoxyguanosine kinase, better substrate than deoxyguanosine kinase Homo sapiens ADP + arabinosyl guanine 5'-monophosphate
-
?
ATP + deoxyadenosine recombinant mitochondrial deoxyguanosine kinase Homo sapiens ADP + dAMP
-
?
ATP + deoxycytidine recombinant mitochondrial deoxyguanosine kinase Homo sapiens ADP + dCMP
-
?
ATP + deoxyinosine recombinant mitochondrial deoxyguanosine kinase Homo sapiens ADP + dIMP
-
?
ATP + deoxyinosine recombinant mitochondrial deoxyguanosine kinase, may be the preferred substrate in vivo Homo sapiens ADP + dIMP
-
?
ATP + dideoxyinosine recombinant mitochondrial deoxyguanosine kinase, very low activity Homo sapiens ADP + dideoxyinosine 5'-monophosphate
-
?