2.1.1.8: histamine N-methyltransferase
This is an abbreviated version!
For detailed information about histamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.8
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2.1.1.8
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diamine
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histaminergic
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metoprine
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thr105ile
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l-histidine
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radioenzymatic
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thioperamide
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tele-methylhistamine
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aminoguanidine
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histamine-induced
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amodiaquine
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s-adenosyl-l-homocysteine
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3hhistamine
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histamine-related
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histamine-degrading
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n-myristoyltransferase
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pentagastrin
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gene-dose
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mepyramine
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pyrilamine
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phenylethanolamine
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r-alpha-methylhistamine
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histaminase
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medicine
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dimaprit
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degradation
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analysis
- 2.1.1.8
-
diamine
-
histaminergic
- metoprine
-
thr105ile
- l-histidine
-
radioenzymatic
- thioperamide
-
tele-methylhistamine
- aminoguanidine
-
histamine-induced
- amodiaquine
- s-adenosyl-l-homocysteine
-
3hhistamine
-
histamine-related
-
histamine-degrading
- n-myristoyltransferase
- pentagastrin
-
gene-dose
-
mepyramine
-
pyrilamine
- phenylethanolamine
-
r-alpha-methylhistamine
- histaminase
- medicine
- dimaprit
- degradation
- analysis
Reaction
Synonyms
histamine 1-methyltransferase, histamine methyltransferase, histamine N-methyltransferase, histamine-methylating enzyme, histamine-N-methyltransferase, HMT, HNMT, imidazole methyltransferase, imidazole N-methyltransferase, imidazolemethyltransferase, methyltransferase, histamine, Ntau-methyltransferase, S-adenosylmethionine-histamine N-methyltransferase
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General Information
General Information on EC 2.1.1.8 - histamine N-methyltransferase
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physiological function
in HNMT knockout mice, HNMT deficiency enhances brain histamine concentrations. The mice exhibit highly aggressive behaviours in the resident-intruder and aggressive biting behaviour tests. Aggression is suppressed by treatment with zolantidine, a histamine H2 receptor (H2R) antagonist. Knockout mice exhibit prolonged bouts of awakening during the light (inactive) period and compensatorysleep during the dark (active) period. Abnormal sleep behaviour is suppressed by treatment with pyrilamine, a H1R antagonist, prior to light period