2.1.1.8: histamine N-methyltransferase
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For detailed information about histamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.8
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2.1.1.8
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diamine
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histaminergic
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metoprine
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thr105ile
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l-histidine
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radioenzymatic
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thioperamide
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tele-methylhistamine
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aminoguanidine
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histamine-induced
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amodiaquine
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s-adenosyl-l-homocysteine
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3hhistamine
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histamine-related
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histamine-degrading
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n-myristoyltransferase
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pentagastrin
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gene-dose
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mepyramine
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pyrilamine
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phenylethanolamine
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r-alpha-methylhistamine
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histaminase
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medicine
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dimaprit
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degradation
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analysis
- 2.1.1.8
-
diamine
-
histaminergic
- metoprine
-
thr105ile
- l-histidine
-
radioenzymatic
- thioperamide
-
tele-methylhistamine
- aminoguanidine
-
histamine-induced
- amodiaquine
- s-adenosyl-l-homocysteine
-
3hhistamine
-
histamine-related
-
histamine-degrading
- n-myristoyltransferase
- pentagastrin
-
gene-dose
-
mepyramine
-
pyrilamine
- phenylethanolamine
-
r-alpha-methylhistamine
- histaminase
- medicine
- dimaprit
- degradation
- analysis
Reaction
Synonyms
histamine 1-methyltransferase, histamine methyltransferase, histamine N-methyltransferase, histamine-methylating enzyme, histamine-N-methyltransferase, HMT, HNMT, imidazole methyltransferase, imidazole N-methyltransferase, imidazolemethyltransferase, methyltransferase, histamine, Ntau-methyltransferase, S-adenosylmethionine-histamine N-methyltransferase
ECTree
2.1.1.8 histamine N-methyltransferaseAdvanced search results
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Application on EC 2.1.1.8 - histamine N-methyltransferase
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
analysis
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guinea-pig HNMT has 292 amino acid residues, its sequences are more similar to the human and pig sequences than to the mouse and rat sequences, respectively
degradation
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higher HMT activity seems to be linked to reduced histamine catabolism, percentage of catabolized histamine is not correlated to individual mannitol fluxes and appears to be independent of paracellular permeability
medicine
medicine
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in patients with food allergy, median enzyme activity, as well as median diamone oxidase activity, are significantly decreased compared to controls. Histamine content is elevated
medicine
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T105I mutation is more abundant among alcoholics from Finnish Caucasion and Plains Indian American populations. Decreased histamine level in central nervous system may be a risk factor in alcoholism and associated with higher levels of trait anxiety
medicine
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elevation of endogenous histamine by amodiaquine may play a protective role through the regulation of TNF-alpha production in endotoxin-induced hepatic injury mice
medicine
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in German Caucasians the association of the HNMT Thr105Ile polymorphism with alcoholism is not replicated, but a congruent association is found between the Ile105 allele and family history of alcoholism supporting the protective role of the Ile105 allele against alcoholism
medicine
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results suggest that alterations of histamine homeostasis are associated with the risk of movement disorders
medicine
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the HNMT T314 allele frequency is lower in Chinese population than in American Caucasians. No association can be found in the involvement of HNMT C314T polymorphism in the susceptibility to duodenal ulcer
medicine
Iodinated contrast media can cause pseudoallergic reactions associated with histamine release in significant numbers of patients. The iodinated contrast media tested in vitro do not exhibit inhibition of histamine inactivating enzymes diamine oxidase and histamine N-methyltransferase at physiologically relevant concentrations
medicine
histamine-N-methyltransferase is increased in atopic dermatitis patients and atopic dermatitis model mice. Micro-RNA miR-223 is upregulated in the whole blood cells of a large group of atopic dermatitis patients. HNMT expression is not inhibited by miR-223
