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2.1.1.8: histamine N-methyltransferase

This is an abbreviated version!
For detailed information about histamine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.8

Reaction

S-adenosyl-L-methionine
+
histamine
=
S-adenosyl-L-homocysteine
 +
Ntau-methylhistamine

Synonyms

histamine 1-methyltransferase, histamine methyltransferase, histamine N-methyltransferase, histamine-methylating enzyme, histamine-N-methyltransferase, HMT, HNMT, imidazole methyltransferase, imidazole N-methyltransferase, imidazolemethyltransferase, methyltransferase, histamine, Ntau-methyltransferase, S-adenosylmethionine-histamine N-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.8 histamine N-methyltransferase

Temperature Stability

Temperature Stability on EC 2.1.1.8 - histamine N-methyltransferase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
90 min, 1 mM dithiothreitol, stable, 40% loss of activity without addition of dithiothreitol
48.4
melting temperature, mutant L208R
53.7
melting temperature, mutant L208K
57.8
melting temperature, mutant L208V
60.4
melting temperature, wild-type, presence of histamine, and melting temeprature of mutant L208F
61.3
melting temperature, wild-type
61.5
melting temperature, wild-type, presence of S-adenosyl-L-methionine