2.1.1.8: histamine N-methyltransferase

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For detailed information about histamine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

histamine 1-methyltransferase, histamine methyltransferase, histamine N-methyltransferase, histamine-methylating enzyme, histamine-N-methyltransferase, HMT, HNMT, imidazole methyltransferase, imidazole N-methyltransferase, imidazolemethyltransferase, methyltransferase, histamine, Ntau-methyltransferase, S-adenosylmethionine-histamine N-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.8 histamine N-methyltransferase

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Results	in table
8	Activating Compound
280	AA Sequence
10	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
299	Disease/ Diagnostics
1	Expression
1	General Information
1	General Stability
114	Inhibitors
7	Ki Value [mM]
29	KM Value [mM]
5	Localization
11	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
66	Organism
3	Pathway
12	PDB ID
15	pH Optimum
2	pH Range
17	Protein Variants
16	Purification (Commentary)
5	Reaction
2	Reaction Type
66	Reference
138	Source Tissue
21	Specific Activity [micromol/min/mg]
5	Storage Stability
51	Substrates and Products (Substrate)
13	Subunits
37	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
7	Temperature Stability [°C]
4	Turnover Number [1/s]

pH Range

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pH Range on EC 2.1.1.8 - histamine N-methyltransferase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

6.5 - 10.5

Sus scrofa

-

about 50% of maximum activity at pH 6.5 and pH 10.5, N-methylhistamine

441558

7.3 - 10.3

Rattus norvegicus

-

about 50% of maximum activity at pH 7.3 and pH 10.3

441561