2.1.1.8: histamine N-methyltransferase
This is an abbreviated version!
For detailed information about histamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.8
-
2.1.1.8
-
diamine
-
histaminergic
-
metoprine
-
thr105ile
-
l-histidine
-
radioenzymatic
-
thioperamide
-
tele-methylhistamine
-
aminoguanidine
-
histamine-induced
-
amodiaquine
-
s-adenosyl-l-homocysteine
-
3hhistamine
-
histamine-related
-
histamine-degrading
-
n-myristoyltransferase
-
pentagastrin
-
gene-dose
-
mepyramine
-
pyrilamine
-
phenylethanolamine
-
r-alpha-methylhistamine
-
histaminase
-
medicine
-
dimaprit
-
degradation
-
analysis
- 2.1.1.8
-
diamine
-
histaminergic
- metoprine
-
thr105ile
- l-histidine
-
radioenzymatic
- thioperamide
-
tele-methylhistamine
- aminoguanidine
-
histamine-induced
- amodiaquine
- s-adenosyl-l-homocysteine
-
3hhistamine
-
histamine-related
-
histamine-degrading
- n-myristoyltransferase
- pentagastrin
-
gene-dose
-
mepyramine
-
pyrilamine
- phenylethanolamine
-
r-alpha-methylhistamine
- histaminase
- medicine
- dimaprit
- degradation
- analysis
Reaction
Synonyms
histamine 1-methyltransferase, histamine methyltransferase, histamine N-methyltransferase, histamine-methylating enzyme, histamine-N-methyltransferase, HMT, HNMT, imidazole methyltransferase, imidazole N-methyltransferase, imidazolemethyltransferase, methyltransferase, histamine, Ntau-methyltransferase, S-adenosylmethionine-histamine N-methyltransferase
ECTree
2.1.1.8 histamine N-methyltransferaseAdvanced search results
results (
results (Engineering
Engineering on EC 2.1.1.8 - histamine N-methyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C314T
-
PCR reaction-restriction fragment length polymorphism assay is used to identify the polymorphism of the point mutation C314T of HNMT gene of 498 Chinese patients with duodenal ulcer and 151 healthy individuals. In normal controls, the allele frequency of HNMT T314 is 3.3%, which is significantly lower than American Caucasians. The HNMT T314 allele is detected in 3.5% of the duodenal ulcer patients. In cases and controls, the frequency of C/C genotypes are 93.0% and 93.4%, respectively. The HNMT T/T genotype is not found in this population. No significant differences is seen in both genotype frequencies and allele frequencies between duodenal ulcer groups and controls
L208F
21% of wild-type activtiy, Michaelis-Menten parameters for SAM and histamine similar to wild-type
L208K
substantial loss of enzymatic activity and binding affinity for histamine
L208R
substantial loss of enzymatic activity and binding affinity for histamine
L208V
48% of wild-type activity, Michaelis-Menten parameters for SAM and histamine similar to wild-type
T105I
additional information
T105I
common threonine-isoleucine polymorphism at residue 105, showing decreased activity and lower protein levels than the 105T protein. Molecular dynamic simulations at 37°C indicate that replacing Thr with the larger Ile residue leads to greater burial of residue 105 and heightened intramolecular interactions between residue 105 and residues within helix R3 and strand a3. This altered, tighter packing is translated to the active site, resulting in the reorientation of several cosubstrate-binding residues
T105I
-
Thr105Ile polymorphism is analyzed whether it is associated with alcoholism in German Caucasians. No significant difference is found in the frequency of the Ile105 allele between alcoholics and controls. Likewise, genotype distributions does not differ significantly. Frequency of the Ile105 allele is significantly lower in male alcoholics with a family history of alcoholism compared to that in male alcoholics without a family history of alcoholism
T105I
-
Thr105Ile polymorphism of the HNMT enzyme is analyzed in patients with essential tremor. Leukocytary DNA from 204 essential tremor patients and a control group of 295 unrelated healthy individuals is studied for the nonsynonymous HNMT Thr105Ile polymorphism by using amplification-restriction analyses. Patients with essential tremor show a higher frequency of homozygous HNMT 105Thr genotypes leading to high metabolic activity with a statistically significant gene-dose effect, as compared to healthy subjects
T105I
an association of the HNMT Thr105Ile polymorphism with Parkinsons disease is observed
additional information
-
the A939G polymorphism is significantly associated with the aspirin intolerant chronic urticaria phenotype, while no association is found with the C314T polymorphism, the 939A allele gives lower levels of HNMT mRNA stability, HNMT protein expression, and HNMT enzymatic activity and higher histamine release than the 939G allele, patients with the 939A allele have lower HNMT activity in red blood cell lysates and higher histamine release from their basophils
additional information
-
subcutaneous injection of amodiaquine in mice with propionibacterium acnes-primed and lipopolysaccharide (LPS)-induced hepatitis significantly increases the histamine levels in the liver in comparison to saline treated mice. Pretreatment with amodiaquine also improves the survival rate of the hepatitis mice, and this improvement is partially associated with the decrease in serum levels of aspartate aminotransferase and alanine aminotransferase. Amodiaquine partially suppresses increases of tumor necrosis factor (TNF)-alpha in the serum and TNF-alpha mRNA expression in the liver
