2.1.1.67: thiopurine S-methyltransferase

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For detailed information about thiopurine S-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.67

2.1.1.67

azathioprine

6-mercaptopurine

bowel

pharmacogenetics

children

lymphoblastic

leukemia

myelosuppression

erythrocyte

tpmt*2

crohn

thioguanine

dosing

s-methylation

autoimmune

marrow

remission

caucasian

leukopenia

myelotoxicity

ulcerative

6-methylmercaptopurine

methotrexate

ethnic

inosine

colitis

azathioprine-induced

medicine

allele-specific

interindividual

nudt15

5-aminosalicylic

thiopurine-induced

allopurinol

pancytopenia

neutropenia

dihydropyrimidine

infliximab

drug-metabolizing

pyrophosphohydrolase

trimodal

hematotoxicity

analysis

nudix

pemphigus

diagnostics

mofetil

Reaction

Synonyms

6-thiopurine S-methyltransferase, 6-thiopurine transmethylase, mercaptopurine methyltransferase, thiopurine methyl transferase, thiopurine methyltransferase, thiopurine S-methyltransferase, thiopurine-S-methyl-transferase, TMPT, TPMT

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.67 thiopurine S-methyltransferase

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Results	in table
2	Activating Compound
5446	AA Sequence
54	Application
1	CAS Registry Number
19	Cloned(Commentary)
1	Crystallization (Commentary)
1052	Disease/ Diagnostics
7	Expression
3	General Information
1	General Stability
18	IC50 Value
99	Inhibitors
24	Ki Value [mM]
103	KM Value [mM]
30	Localization
1	Metals/Ions
8	Molecular Weight [Da]
65	Natural Substrates/ Products (Substrates)
118	Organism
1	Pathway
10	PDB ID
13	pH Optimum
1	pH Range
171	Protein Variants
12	Purification (Commentary)
1	Reaction
44	Reaction Type
108	Reference
148	Source Tissue
11	Specific Activity [micromol/min/mg]
1	Storage Stability
297	Substrates and Products (Substrate)
2	Subunits
156	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
5	Temperature Stability [°C]

Purification

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Purification on EC 2.1.1.67 - thiopurine S-methyltransferase

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2 isozymes

cytosolic fractions of transformed Saccharomyces cerevisiae cells are prepared

Homo sapiens

P51580

685039

Ni-NTA column chromatography and Superdex 200 gel filtration

2 entries

Ni-NTA column chromatography and Superdex S200 gel filtration

partially

using a Ni2+-NTA resin and a gel-filtration column

2 entries