2.1.1.67: thiopurine S-methyltransferase
This is an abbreviated version!
For detailed information about thiopurine S-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.67
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2.1.1.67
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azathioprine
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6-mercaptopurine
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bowel
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pharmacogenetics
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children
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lymphoblastic
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leukemia
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myelosuppression
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erythrocyte
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tpmt*2
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crohn
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thioguanine
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dosing
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s-methylation
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autoimmune
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marrow
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remission
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caucasian
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leukopenia
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myelotoxicity
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ulcerative
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6-methylmercaptopurine
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methotrexate
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ethnic
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inosine
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colitis
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azathioprine-induced
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medicine
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allele-specific
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interindividual
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nudt15
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5-aminosalicylic
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thiopurine-induced
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allopurinol
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pancytopenia
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neutropenia
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dihydropyrimidine
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infliximab
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drug-metabolizing
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pyrophosphohydrolase
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trimodal
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hematotoxicity
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analysis
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nudix
-
pemphigus
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diagnostics
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mofetil
- 2.1.1.67
- azathioprine
- 6-mercaptopurine
- bowel
-
pharmacogenetics
- children
- lymphoblastic
- leukemia
-
myelosuppression
- erythrocyte
-
tpmt*2
- crohn
- thioguanine
-
dosing
-
s-methylation
- autoimmune
- marrow
-
remission
-
caucasian
- leukopenia
-
myelotoxicity
-
ulcerative
- 6-methylmercaptopurine
- methotrexate
-
ethnic
- inosine
- colitis
-
azathioprine-induced
- medicine
-
allele-specific
-
interindividual
-
nudt15
-
5-aminosalicylic
-
thiopurine-induced
- allopurinol
- pancytopenia
- neutropenia
- dihydropyrimidine
-
infliximab
-
drug-metabolizing
-
pyrophosphohydrolase
-
trimodal
-
hematotoxicity
- analysis
-
nudix
- pemphigus
- diagnostics
- mofetil
Reaction
Synonyms
6-thiopurine S-methyltransferase, 6-thiopurine transmethylase, mercaptopurine methyltransferase, thiopurine methyl transferase, thiopurine methyltransferase, thiopurine S-methyltransferase, thiopurine-S-methyl-transferase, TMPT, TPMT
ECTree
2.1.1.67 thiopurine S-methyltransferaseAdvanced search results
results (
results (KM Value
KM Value on EC 2.1.1.67 - thiopurine S-methyltransferase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
additional information
additional information
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various thiophenols as substrates, Km 0.0008-0.0078
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0.0137
6-thioguanine
mutant L69V, cytosolic fraction of yeast cells is incubated with 500 microM of 6-TG and 0-400 microM of SAM
0.0188
6-thioguanine
1.2fold increase in KM-value compared to wild-type variant
0.03435
6-thioguanine
wild-type enzyme, cytosolic fraction of yeast cells is incubated with 500 microM of 6-TG and 0-400 microM of SAM
0.0448
6-thioguanine
2.9fold increase in KM-value compared to wild-type variant
0.0555
6-thioguanine
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the Km-value of the variant Ser125Leu is 1.6fold higher than the Km-value of the wild-type variant, the ratio of Vmax to Km-value is 27% of the wild-type ratio
0.0562
6-thioguanine
mutant L69V, cytosolic fraction of yeast cells is incubated with 0-350 microM of 6-TG and 1mM of SAM
0.0627
6-thioguanine
wild-type enzyme, cytosolic fraction of yeast cells is incubated with 0-350 microM of 6-TG and 1mM of SAM
0.0635
6-thioguanine
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the Km-value of the variant Gly144Arg is 1.8fold higher than the Km-value of the wild-type variant, the ratio of Vmax to Km-value is 31% of the wild-type ratio
0.072
6-thioguanine
mutant C212R, cytosolic fraction of yeast cells is incubated with 0-350 microM of 6-TG and 1mM of SAM
0.0759
6-thioguanine
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the Km-value of the variant Glu28Val is 2.2fold higher than the Km-value of the wild-type variant, the ratio of Vmax to KM-value is 58% of the wild-type ratio
0.07985
6-thioguanine
mutant K119T, cytosolic fraction of yeast cells is incubated with 0-350 microM of 6-TG and 1mM of SAM
0.08305
6-thioguanine
mutant Q179H, cytosolic fraction of yeast cells is incubated with 0-350 microM of 6-TG and 1mM of SAM
0.1799
6-thioguanine
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the Km-value of the variant Gly144Arg is 5.1fold higher than the Km-value of the wild-type variant, the ratio of Vmax to KM-value is 10.4% of the wild-type ratio
