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2.1.1.67: thiopurine S-methyltransferase

This is an abbreviated version!
For detailed information about thiopurine S-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.67

Reaction

S-adenosyl-L-methionine
+
a thiopurine
=
S-adenosyl-L-homocysteine
+
a thiopurine S-methylether

Synonyms

6-thiopurine S-methyltransferase, 6-thiopurine transmethylase, mercaptopurine methyltransferase, thiopurine methyl transferase, thiopurine methyltransferase, thiopurine S-methyltransferase, thiopurine-S-methyl-transferase, TMPT, TPMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.67 thiopurine S-methyltransferase

KI Value

KI Value on EC 2.1.1.67 - thiopurine S-methyltransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.027
2-Hydroxy-6-mercaptopurine
-
-
0.01 - 0.0113
3,4-dimethoxy-5-hydroxybenzoic acid
0.00802 - 0.0113
6-Mercaptopurine
0.45 - 0.9
6-thioguanine
2.413
celecoxib
-
-
0.722
diclofenac
-
-
1.524
flurbiprofen
-
-
1.043
Ibuprofen
-
-
0.172
Ketoprofen
-
-
1.41
lornoxicam
-
-
0.039
Mefenamic acid
-
-
4.238
meloxicam
-
-
4.3
nabumetone
-
-
0.052
naproxen
-
-
0.208
olsalazine
-
-
5.162
paracetamol
-
-
2.589
piroxicam
-
-
0.00075
S-adenosyl-L-homocysteine
-
-
0.05
tolfenamic acid
-
-
0.85
tropolone
-
-