Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.1.1.67: thiopurine S-methyltransferase

This is an abbreviated version!
For detailed information about thiopurine S-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.67

Reaction

S-adenosyl-L-methionine
+
a thiopurine
=
S-adenosyl-L-homocysteine
+
a thiopurine S-methylether

Synonyms

6-thiopurine S-methyltransferase, 6-thiopurine transmethylase, mercaptopurine methyltransferase, thiopurine methyl transferase, thiopurine methyltransferase, thiopurine S-methyltransferase, thiopurine-S-methyl-transferase, TMPT, TPMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.67 thiopurine S-methyltransferase

Engineering

Engineering on EC 2.1.1.67 - thiopurine S-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
238G>C
460G>A
460G>A/719A>G
-
TPMT*3A polymorphism, low or no TPMT activity
539A>T
-
TPMT variant
719A>G
A154T
A154T/Y240C
A154Y
-
thiopurine S-methyltransferase polymorphism, G to A transition at position 460
A167G
A179G/G460A
the variant is associated with low enzyme activity
A180P
-
the mutation affects TMPT activity
A719G
C132Y
C212R
C216T
the mutant exhibits reduced activity compared to the wild type enzyme
E98X
-
the mutation affects TMPT activity
F208L
-
the mutation is associated with a decrease in enzyme activity
G144R
G238C
G460A
H227Q
K119T
K122T
K238E
Q179H
polymorphism c.537G>T, TPMT*24
R152A
mutant to probe, whether this residue is important for catalysis
R152A/R226A
mutant to probe, whether this residue is important for catalysis
R152E
mutant to probe, whether this residue is important for catalysis
R152H
mutant to probe, whether this residue is important for catalysis
R163H
R163P
R215H
R226A
mutant to probe, whether this residue is important for catalysis
R226E
mutant to probe, whether this residue is important for catalysis
R226H
mutant to probe, whether this residue is important for catalysis
S125L
TPMT*2
TPMT*23
-
polymorphism, single nucleotide substitution, C500G
TPMT*3A
TPMT*3B
TPMT*3C
Y107D
the mutant shows less than 10% activity compared to the wild type enzyme, the variant allozyme shows a striking decrease in both immunoreactive protein level and enzyme activity after transient expression in COS-1 cells, the mutant is less stable than the wild type TPMT allozyme
Y180F
Y240C
A154T
-
polymorphism TPMT*3B
A154T/Y240C
-
polymorphism TPMT*3A
A154T/Y240C/E98STOP
-
polymorphism TPMT*3D
A80P
-
polymorphism TPMT*2
C132Y
-
polymorphism TPMT*11
E28V
-
polymorphism TPMT*13
G144R
-
polymorphism TPMT*10
G36S/K238E
-
polymorphism TPMT*20
G71R
-
polymorphism TPMT*18
H227E
-
polymorphism TPMT*7
K122T
-
polymorphism TPMT*19
L49S
-
polymorphism TPMT*5
L69V
-
polymorphism TPMT*21
Q42E
-
polymorphism TPMT*17
R163H
-
polymorphism TPMT*16
R163P
-
polymorphism TPMT*22
R215H
-
polymorphism TPMT*8
S125L
-
polymorphism TPMT*12
Y180F
-
polymorphism TPMT*6
Y240C
-
polymorphism TPMT*3C
additional information