1.8.1.12: trypanothione-disulfide reductase
This is an abbreviated version!
For detailed information about trypanothione-disulfide reductase, go to the full flat file.
Word Map on EC 1.8.1.12
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1.8.1.12
-
trypanosoma
-
leishmania
-
cruzi
-
chagas
-
trypanosomatids
-
leishmaniasis
-
brucei
-
trypanocidal
-
antileishmanial
-
donovani
-
promastigotes
-
trypanosomiasis
-
infantum
-
amastigotes
-
fasciculata
-
antitrypanosomal
-
crithidia
-
antiparasitic
-
flavoenzyme
-
phenothiazine
-
medicine
-
epimastigotes
-
nifurtimox
-
amazonensis
-
antiprotozoal
-
trypomastigotes
-
tryparedoxin
-
kinetoplastida
-
leishmanicidal
-
congolense
-
rhodesiense
-
miltefosine
-
antimonial
-
ts2
-
n1,n8-bisglutathionylspermidine
-
benznidazole
-
clomipramine
-
glutathionylspermidine
-
antichagasic
-
thioridazine
-
ovothiols
-
nitrofuran
-
trypanothione-dependent
-
pharmacology
- 1.8.1.12
- trypanosoma
- leishmania
- cruzi
- chagas
-
trypanosomatids
- leishmaniasis
- brucei
-
trypanocidal
-
antileishmanial
- donovani
- promastigotes
- trypanosomiasis
- infantum
- amastigotes
- fasciculata
-
antitrypanosomal
- crithidia
-
antiparasitic
-
flavoenzyme
- phenothiazine
- medicine
- epimastigotes
- nifurtimox
- amazonensis
-
antiprotozoal
- trypomastigotes
- tryparedoxin
- kinetoplastida
-
leishmanicidal
- congolense
- rhodesiense
- miltefosine
-
antimonial
- ts2
-
n1,n8-bisglutathionylspermidine
- benznidazole
- clomipramine
- glutathionylspermidine
-
antichagasic
- thioridazine
-
ovothiols
-
nitrofuran
-
trypanothione-dependent
- pharmacology
Reaction
Synonyms
EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR
ECTree
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KCat KM Value
KCat KM Value on EC 1.8.1.12 - trypanothione-disulfide reductase
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4
mutant enzyme E436A, pH and temperature not specified in the publication
250
trypanothione disulfide
in the presence of 0.03 mM 4-((1-(4-ethylphenyl)-2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-3-yl)methyl)thiomorpholine, at 20°C, pH not specified in the publication
300
trypanothione disulfide
mutant enzyme W81A, pH and temperature not specified in the publication
340
trypanothione disulfide
in the presence of 0.01 mM 4-((1-(4-ethylphenyl)-2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-3-yl)methyl)thiomorpholine, at 20°C, pH not specified in the publication
470
trypanothione disulfide
in the absence of 4-((1-(4-ethylphenyl)-2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-3-yl)methyl)thiomorpholine, at 20°C, pH not specified in the publication
1500
trypanothione disulfide
wild type enzyme, pH and temperature not specified in the publication
1600
trypanothione disulfide
mutant enzyme Q439A, pH and temperature not specified in the publication