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1.8.1.12: trypanothione-disulfide reductase

This is an abbreviated version!
For detailed information about trypanothione-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.12

Reaction

trypanothione
+
NADP+
=
trypanothione disulfide
 +
NADPH
 +
H+

Synonyms

EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.12 trypanothione-disulfide reductase

Cloned

Cloned on EC 1.8.1.12 - trypanothione-disulfide reductase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloned into expression vector and expressed in wild-type cells
-
cloned into expression vector and overexpressed in Leishmania donovani and in Trypanosoma cruzi
-
DNA and amino acid sequence determination and analysis, overexpression in Escherichia coli strain BL21(DE3) as soluble glutathione-S-transferase fusion protein
DNA sequence analysis
-
expressed in Escherichia coli
-
expressed in Escherichia coli BL21 Star (DE3)pLysS cells
expressed in Escherichia coli BL21(DE3) cells
expression in Escherichia coli
expression in Escherichia coli, sequence analysis
-
expression of wild-type and mutant enzymes in Escherichia coli
-
gene EHTR, DNA and amino acid sequence determination and analysis, phylogenetic analysis
mutant enzyme glutathione reductase-trypanothine reductase, expression in Escherichia coli
-
overexpression in Escherichia coli
-
overexpression of wild-type and mutants C53S, C53A, C58S in Escherichia coli
-
replacement clones of tyrA, cloning of replacement vector, several genotypes
-
single copy gene
-