1.8.1.12: trypanothione-disulfide reductase

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For detailed information about trypanothione-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.12

1.8.1.12

trypanosoma

leishmania

cruzi

chagas

trypanosomatids

leishmaniasis

brucei

trypanocidal

antileishmanial

donovani

promastigotes

trypanosomiasis

infantum

amastigotes

fasciculata

antitrypanosomal

crithidia

antiparasitic

flavoenzyme

phenothiazine

medicine

epimastigotes

nifurtimox

amazonensis

antiprotozoal

trypomastigotes

tryparedoxin

kinetoplastida

leishmanicidal

congolense

rhodesiense

miltefosine

antimonial

ts2

n1,n8-bisglutathionylspermidine

benznidazole

clomipramine

glutathionylspermidine

antichagasic

thioridazine

ovothiols

nitrofuran

trypanothione-dependent

pharmacology

Reaction

Synonyms

EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR

ECTree

1 Oxidoreductases

1.8 Acting on a sulfur group of donors

1.8.1 With NAD⁺ or NADP⁺ as acceptor

1.8.1.12 trypanothione-disulfide reductase

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Results	in table
47	Activating Compound
79	AA Sequence
37	Application
1	CAS Registry Number
21	Cloned(Commentary)
192	Cofactor
17	Crystallization (Commentary)
177	Disease/ Diagnostics
15	General Information
3	General Stability
420	IC50 Value
940	Inhibitors
8	kcat/KM [mM/s]
153	Ki Value [mM]
67	KM Value [mM]
2	Localization
25	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
194	Organism
4	Pathway
94	PDB ID
19	pH Optimum
3	pH Range
1	pI Value
12	Protein Variants
21	Purification (Commentary)
13	Reaction
3	Reaction Type
160	Reference
1	Renatured (Commentary)
35	Source Tissue
23	Specific Activity [micromol/min/mg]
219	Substrates and Products (Substrate)
32	Subunits
201	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
42	Turnover Number [1/s]

pH Range

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pH Range on EC 1.8.1.12 - trypanothione-disulfide reductase

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6 - 11

Leishmania infantum

less than 15% activity at pH 6.0, about 50% activity at pH 6.5, about 80% activity at pH 7.0, 100% activity at pH 7.5, about 35% activity at pH 8.0, around 30% activity between pH 8.5 and 11.0, no activity at pH 12.0 and less than pH 5.0

723967

6.5 - 9

2 entries