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1.8.1.12: trypanothione-disulfide reductase

This is an abbreviated version!
For detailed information about trypanothione-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.12

Reaction

trypanothione
+
NADP+
=
trypanothione disulfide
 +
NADPH
 +
H+

Synonyms

EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.12 trypanothione-disulfide reductase

Turnover Number

Turnover Number on EC 1.8.1.12 - trypanothione-disulfide reductase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.67
(E,Z)-ajoene
-
-
4.8 - 24.5
1,4-benzoquinone
21.8
4-aminobutyryl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
-
-
125
5,5'-dithiobis(N-[3-(4-methylpiperazin-1-yl)propyl]-2-nitrobenzamide)
-
recombinant enzyme
125
5,5'-dithiobis(N-[3-(dimethylamino)propyl]-2-nitrobenzamide)
-
recombinant enzyme
2.9 - 29
9,10-phenanthrenequinone
83.3
deazatrypanothione disulfide
-
-
85.4 - 242
glutathionylspermidine disulfide
61.3
L-beta-aspartyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
-
-
53.2
L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
-
-
818
L-gamma-glutamyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
-
-
109
N-benzyloxycarbonyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
-
-
0.21 - 6.33
NADPH
101
tert-butyloxycarbonyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide
-
-
0.19 - 7.02
thio-NADPH
0.8 - 517
trypanothione disulfide