1.21.1.1: iodotyrosine deiodinase

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For detailed information about iodotyrosine deiodinase, go to the full flat file.

Reaction

Synonyms

DEHAL1, Dehal1 protein, DEHAL1B, EC 1.22.1.1, iodotyrosine dehalogenase 1, iodotyrosine deiodinase, IYD, lyd, NADH oxidase/flavin reductase, SUP-18, SUP-18 IYD, TDH

ECTree

     1 Oxidoreductases

         1.21 Catalysing the reaction X-H + Y-H = X-Y

             1.21.1 With NAD⁺ or NADP⁺ as acceptor

                1.21.1.1 iodotyrosine deiodinase

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69	Disease/ Diagnostics
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15	General Information
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199	Organism
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Reaction

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Reaction on EC 1.21.1.1 - iodotyrosine deiodinase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

3-iodo-L-tyrosine + NADP+ + iodide = 3,5-diiodo-L-tyrosine + NADPH + H+

(1b)

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L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+

overall reaction

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L-tyrosine + NADP+ + iodide = 3-iodo-L-tyrosine + NADPH + H+

(1a)

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