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1.21.1.1: iodotyrosine deiodinase

This is an abbreviated version!
For detailed information about iodotyrosine deiodinase, go to the full flat file.

Word Map on EC 1.21.1.1

Reaction

3-iodo-L-tyrosine
+
NADP+
 +
Iodide
=
3,5-diiodo-L-tyrosine
 +
NADPH
 +
H+

Synonyms

DEHAL1, Dehal1 protein, DEHAL1B, EC 1.22.1.1, iodotyrosine dehalogenase 1, iodotyrosine deiodinase, IYD, lyd, NADH oxidase/flavin reductase, SUP-18, SUP-18 IYD, TDH

ECTree

     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
             1.21.1 With NAD+ or NADP+ as acceptor
                1.21.1.1 iodotyrosine deiodinase

Cloned

Cloned on EC 1.21.1.1 - iodotyrosine deiodinase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
expressed in Sf9 insect cells and in Escherichia coli
expression in HEK-293 cell
expression in HEK-293T cell
-
expression of a derivative lacking codons for amino acids 2–33 to gain a soluble protein
gene DEHAL1, DNA and amino acid sequence determination and analysis, genotyping of healthy and iodotyrosine deiodinase deficiency samples
gene DEHAL1, recombinant expression of N-terminally SUMO-tagged enzyme in Escherichia coli strain Rosetta 2(DE3)
gene sup-18, genotyping, encodes the Caenorhabditis elegans orthologue of mammalian iodotyrosine deiodinase (IYD)
quantitative RT-PCR enzyme expression analysis, overview
-
transfection of HEK-293 cells results in active protein, but not of CHO cells