1.21.1.1: iodotyrosine deiodinase
This is an abbreviated version!
For detailed information about iodotyrosine deiodinase, go to the full flat file.
Word Map on EC 1.21.1.1
-
1.21.1.1
-
thyroid
-
iodide
-
deiodination
-
hypothyroidism
-
diiodotyrosine
-
thyroglobulin
-
dehalogenation
-
halotyrosines
-
iodothyronine
-
nitroreductase
-
goiter
-
bromo
-
chlorotyrosine
-
organification
-
diagnostics
-
synthesis
-
medicine
- 1.21.1.1
- thyroid
- iodide
-
deiodination
- hypothyroidism
- diiodotyrosine
- thyroglobulin
-
dehalogenation
-
halotyrosines
-
iodothyronine
- nitroreductase
- goiter
-
bromo
-
chlorotyrosine
-
organification
- diagnostics
- synthesis
- medicine
Reaction
Synonyms
DEHAL1, Dehal1 protein, DEHAL1B, EC 1.22.1.1, iodotyrosine dehalogenase 1, iodotyrosine deiodinase, IYD, lyd, NADH oxidase/flavin reductase, SUP-18, SUP-18 IYD, TDH
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Reference
Reference on EC 1.21.1.1 - iodotyrosine deiodinase
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Gaupale, T.; Mathi, A.; Ravikumar, A.; Bhargava, S.
Localization and enzyme activity of iodotyrosine dehalogenase 1 during metamorphosis of frog Microhyla ornata
Ann. N. Y. Acad. Sci.
1163
402-406
2009
Microhyla ornata
Dumas, P.; Maziere, B.; Autissier, N.; Michel, R.
Specificity of thyroidal and hepatic microsomal iodotyrosine deiodinase
Biochim. Biophys. Acta
293
36-47
1973
Rattus norvegicus
Goswami, A.; Rosenberg, I.
Studies on a soluble thyroid iodotyrosine deiodinase: activation by NADPH and electron carriers
Endocrinology
101
331-341
1977
Bos taurus
Krause, K.; Karger, S.; Gimm, O.; Sheu, S.; Dralle, H.; Tannapfel, A.; Schmid, K.; Dupuy, C.; Fuhrer, D.
Characterisation of DEHAL1 expression in thyroid pathologies
Eur. J. Endocrinol.
156
295-301
2007
Homo sapiens
Gnidehou, S.; Caillou, B.; Talbot, M.; Ohayon, R.; Kaniewski, J.; Noel-Hudson, M.S.; Morand, S.; Agnangji, D.; Sezan, A.; Courtin, F.; Virion, A.; Dupuy, C.
Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site
FASEB J.
18
1574-1576
2004
Homo sapiens (Q6PHW0), Sus scrofa (Q6TA49)
Chiu, K.; Wong, C.
The snake thyroid gland. III. Mono-iodotyrosine deiodinase
Gen. Comp. Endocrinol.
35
93-95
1978
Elaphe taeniurus
McTamney, P.M.; Rokita, S.E.
A mammalian reductive deiodinase has broad power to dehalogenate chlorinated and brominated substrates
J. Am. Chem. Soc.
131
14212-14213
2009
Homo sapiens
Rosenberg, I.; Goswami, A.
Purification and characterization of a flavoprotein from bovine thyroid with iodotyrosine deiodinase activity
J. Biol. Chem.
254
12318-12325
1979
Bos taurus
Goswami, A.; Rosenberg, I.
Characterization of a flavoprotein iodotyrosine deiodinase from bovine thyroid. Flavin nucleotide binding and oxidation-reduction properties
J. Biol. Chem.
254
12326-12330
1979
Bos taurus
Friedman, J.E.; Watson, J.A.; Lam, D.W.; Rokita, S.E.
Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily
J. Biol. Chem.
281
2812-2819
2006
Sus scrofa (Q6TA49), Sus scrofa, Mus musculus (Q9DCX8), Mus musculus
Thomas, S.R.; McTamney, P.M.; Adler, J.M.; Laronde-Leblanc, N.; Rokita, S.E.
Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands
J. Biol. Chem.
284
19659-19667
2009
Mus musculus (Q9DCX8)
Solis-S, J.C.; Villalobos, P.; Orozco, A.; Valverde-R, C.
Comparative kinetic characterization of rat thyroid iodotyrosine dehalogenase and iodothyronine deiodinase type 1
J. Endocrinol.
181
385-392
2004
Rattus norvegicus
Rosenberg, I.
Purification of iodotyrosine deiodinase from bovine thyroid
Metab. Clin. Exp.
19
785-798
1970
Bos taurus
Buss, J.M.; McTamney, P.M.; Rokita, S.E.
Expression of a soluble form of iodotyrosine deiodinase for active site characterization by engineering the native membrane protein from Mus musculus
Protein Sci.
21
351-361
2012
Mus musculus (Q9DCX8), Mus musculus
Phatarphekar, A.; Buss, J.M.; Rokita, S.E.
Iodotyrosine deiodinase: a unique flavoprotein present in organisms of diverse phyla
Mol. Biosyst.
10
86-92
2014
Danio rerio, Hydra vulgaris, Haliscomenobacter hydrossis, Daphnia pulex, Mus musculus (Q9DCX8)
Shimizu, R.; Yamaguchi, M.; Uramaru, N.; Kuroki, H.; Ohta, S.; Kitamura, S.; Sugihara, K.
Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity
Toxicology
314
22-29
2013
Homo sapiens
Iglesias, A.; Garcia-Nimo, L.; Cocho de Juan, J.A.; Moreno, J.C.
Towards the pre-clinical diagnosis of hypothyroidism caused by iodotyrosine deiodinase (DEHAL1) defects
Best Pract. Res. Clin. Endocrinol. Metab.
28
151-159
2014
Homo sapiens (Q6PHW0), Homo sapiens
Bobyk, K.D.; Ballou, D.P.; Rokita, S.E.
Rapid kinetics of dehalogenation promoted by iodotyrosine deiodinase from human thyroid
Biochemistry
54
4487-4494
2015
Homo sapiens
Shimizu, R.
Iodotyrosine deiodinase, a novel target of environmental halogenated chemicals for disruption of the thyroid hormone system in mammals
Biol. Pharm. Bull.
37
1430-1434
2014
Homo sapiens (Q6PHW0), Homo sapiens
Sun, X.; Zhang, X.; Jiang, Y.; Bao, S.; Shan, Z.; Teng, W.
Expression of iodotyrosine deiodinase in thyroid and other organs in iodine-deficient and iodine-excess rats
Biol. Trace Elem. Res.
167
272-279
2015
Rattus norvegicus, Rattus norvegicus Wistar
Hu, J.; Chuenchor, W.; Rokita, S.E.
A switch between one- and two-electron chemistry of the human flavoprotein iodotyrosine deiodinase is controlled by substrate
J. Biol. Chem.
290
590-600
2015
Homo sapiens (Q6PHW0), Homo sapiens
de la Cruz, I.P.; Ma, L.; Horvitz, H.R.
The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9
PLoS Genet.
10
e1004175
2014
Caenorhabditis elegans (Q17374), Caenorhabditis elegans
Sun, Z.; Su, Q.; Rokita, S.E.
The distribution and mechanism of iodotyrosine deiodinase defied expectations
Arch. Biochem. Biophys.
632
77-87
2017
Homo sapiens (Q6PHW0), Homo sapiens
Ingavat, N.; Kavran, J.M.; Sun, Z.; Rokita, S.E.
Active site binding is not sufficient for reductive deiodination by iodotyrosine deiodinase
Biochemistry
56
1130-1139
2017
Homo sapiens (F4KU78), Homo sapiens
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