1.21.1.1: iodotyrosine deiodinase

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For detailed information about iodotyrosine deiodinase, go to the full flat file.

Word Map on EC 1.21.1.1

1.21.1.1

thyroid

iodide

deiodination

hypothyroidism

diiodotyrosine

thyroglobulin

dehalogenation

halotyrosines

iodothyronine

nitroreductase

goiter

bromo

chlorotyrosine

organification

diagnostics

synthesis

medicine

Reaction

Synonyms

DEHAL1, Dehal1 protein, DEHAL1B, EC 1.22.1.1, iodotyrosine dehalogenase 1, iodotyrosine deiodinase, IYD, lyd, NADH oxidase/flavin reductase, SUP-18, SUP-18 IYD, TDH

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.1.1 iodotyrosine deiodinase

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Results	in table
7	Activating Compound
892	AA Sequence
4	Application
12	Cloned(Commentary)
25	Cofactor
5	Crystallization (Commentary)
69	Disease/ Diagnostics
6	Expression
15	General Information
6	IC50 Value
38	Inhibitors
14	kcat/KM [mM/s]
25	KM Value [mM]
10	Localization
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
199	Organism
14	PDB ID
2	pH Optimum
1	pH Range
1	Posttranslational Modification
20	Protein Variants
10	Purification (Commentary)
3	Reaction
33	Reference
2	Renatured (Commentary)
35	Source Tissue
16	Specific Activity [micromol/min/mg]
2	Storage Stability
60	Substrates and Products (Substrate)
9	Subunits
22	Synonyms
1	Systematic Name
17	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 1.21.1.1 - iodotyrosine deiodinase

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body wall muscle

Caenorhabditis elegans

during metamorphosis, DEHAL1 enzyme activity is higher on diiodotyrosine as compared to monoiodotyrosine. Using diiodotyrosine as a substrate, maximal activity is detected at stage 44 in the brain, while it is higher at stage 42 in the tail. With monoiodotyrosine as a substrate, highest activity is detected in the brain at stage 42

ventral part

jaw

tadpole tail fin. During metamorphosis, DEHAL1 enzyme activity is higher on diiodotyrosine as compared to monoiodotyrosine. Using diiodotyrosine as a substrate, maximal activity is detected at stage 44 in the brain, while it is higher at stage 42 in the tail (138.5 U/mg protein). With monoiodotyrosine as a substrate, highest activity is detected in the brain at stage 42

ventricular lining of the fourth ventricle

701712

additional information

2 entries