1.1.1.210: 3beta(or 20alpha)-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 3beta(or 20alpha)-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

5alpha-androstan-3beta,17beta-diol
+
NADP+
=
17beta-hydroxy-5alpha-androstan-3-one
+
NADPH
+
H+

Synonyms

3beta,20alpha-hydroxysteroid oxidoreductase, dehydrogenase, 3beta,20alpha-hydroxy steroid, progesterone reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.210 3beta(or 20alpha)-hydroxysteroid dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.210 - 3beta(or 20alpha)-hydroxysteroid dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
16alpha-(Bromoacetoxy)progesterone
-
competitive inhibition of 3beta- and 20alpha-reductase activity, time dependent and simultaneous, complete inactivation, 2-mercaptoethanol protects
17beta-hydroxy-5alpha-androstan-3-one
19-Nortestosterone 17-bromoacetate
-
competitive inhibition of 3beta- and 20alpha-reductase activity, time dependent and simultaneous, complete inactivation
5alpha-dihydrotestosterone 17-bromoacetate
-
competitive inhibition of 3beta- and 20alpha-reductase activity, time dependent and simultaneous, complete inactivation
progesterone