1.1.1.10: L-xylulose reductase

This is an abbreviated version, for detailed information about L-xylulose reductase, go to the full flat file.

Reaction

xylitol
+
NADP+
=
L-xylulose
+
NADPH
+
H+

Synonyms

DCXR, dicarbonyl/L-xylulose reductase, L-xylulose reductase, LXR3, More, NAD(P)H-dependent xylose reductase, NADP(+)-dependent xylitol dehydrogenase, P31h, P34H, reductase, L-xylulose, XDH, XR, xylitol dehydrogenase, xylose reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.10 L-xylulose reductase

Inhibitors

Inhibitors on EC 1.1.1.10 - L-xylulose reductase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-hydroxybutyric acid
4-methyl-[1,2,3]-thiadiazole-5-carboxylic acid benzyloxyamide
4-methylthiophene-2-carboxylic acid N'-(2,3,3-trichloroacryloyl)-hydrazide
-
IC50: 0.0003 mM for wild-type enzyme, 0.00056 mM for mutant enzyme L143F, 0.002 mM for mutant enzyme H146L, 0.0002 mM for mutant enzyme W191S, 0.0022 mM for mutant enzyme W191F
acetoacetic acid
aminopyrine
-
70 mM
cysteine
-
the addition of cysteine (more than 2 mM) inactivates human L-xylulose reductase and is accompanied by a 10fold decrease in catalytic efficiency, the activity of the cysteine-inactivated enzyme is not recovered by the addition of 10 mM dithiothreitol and 2-mercaptoethanol
fluoride
-
50 mM
heptanoic acid
hexanoic acid
iodoacetate
n-butyric acid
Octanoic acid
50% inhibition at 2.5 mM
oxaloacetic acid
p-chloromercuribenzoate
-
-
pentanoic acid
Phosphate buffer
-
-
-
potassium phosphate
-
when the purified enzyme containing 2 mM 2-mercaptoethanol is diluted with 10 mM potassium phosphate pH 7.0, its diacetyl reductase activity is gradually decreased
propionic acid
Pyruvic acid
threonic acid
additional information
-