BRENDA - Enzyme Database show
show all sequences of 1.1.1.10

Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney

Nakagawa, J.; Ishikura, S.; Asami, J.; Isaji, T.; Usami, N.; Hara, A.; Sakurai, T.; Tsuritani, K.; Oda, K.; Takahashi, M.; Yoshimoto, M.; Otsuka, N.; Kitamura, K.; J. Biol. Chem. 277, 17888-17891 (2002)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
DNA sequence determination and analysis, expression in Escherichia coli strain BL21(DE3)
Cavia porcellus
Inhibitors
Inhibitors
Commentary
Organism
Structure
3-hydroxybutyric acid
50% inhibition at 1.1 mM
Homo sapiens
3-hydroxybutyric acid
50% inhibition at 1.0 mM
Mesocricetus auratus
3-hydroxybutyric acid
50% inhibition at 2.0 mM
Rattus norvegicus
acetoacetic acid
50% inhibition at 0.63 mM
Homo sapiens
acetoacetic acid
50% inhibition at 1.8 mM
Mesocricetus auratus
acetoacetic acid
50% inhibition at 2.5 mM
Rattus norvegicus
heptanoic acid
50% inhibition at 0.38 mM
Homo sapiens
heptanoic acid
50% inhibition at 1.4 mM
Mesocricetus auratus
heptanoic acid
50% inhibition at 2.0 mM
Mus musculus
heptanoic acid
50% inhibition at 2.5 mM
Rattus norvegicus
hexanoic acid
50% inhibition at 0.10 mM
Homo sapiens
hexanoic acid
50% inhibition at 0.40 mM
Mesocricetus auratus
hexanoic acid
50% inhibition at 1.1 mM
Mus musculus
hexanoic acid
50% inhibition at 0.42 mM
Rattus norvegicus
additional information
acetic acid, threonic acid, and octanoic acid are poor inhibitors
Homo sapiens
additional information
acetic acid is a poor inhibitor
Mesocricetus auratus
additional information
acetic acid, acetoacetic acid, 3-OH-butyric acid, and octanoic acid are poor inhibitors
Mus musculus
additional information
acetic acid, oxaloacetic acid, and octanoic acid are poor inhibitors
Rattus norvegicus
n-butyric acid
50% inhibition at 0.064 mM
Homo sapiens
n-butyric acid
50% inhibition at 0.026 mM
Mesocricetus auratus
n-butyric acid
50% inhibition at 0.05 mM
Mus musculus
n-butyric acid
50% inhibition at 0.052 mM
Rattus norvegicus
Octanoic acid
50% inhibition at 2.5 mM
Mesocricetus auratus
oxaloacetic acid
50% inhibition at 0.91 mM
Homo sapiens
oxaloacetic acid
50% inhibition at 2.5 mM
Mesocricetus auratus
oxaloacetic acid
50% inhibition at 2.5 mM
Mus musculus
pentanoic acid
50% inhibition at 0.15 mM
Homo sapiens
pentanoic acid
50% inhibition at 0.20 mM
Mesocricetus auratus
pentanoic acid
50% inhibition at 0.38 mM
Mus musculus
pentanoic acid
50% inhibition at 0.5 mM
Rattus norvegicus
propionic acid
50% inhibition at 0.38 mM
Homo sapiens
propionic acid
50% inhibition at 0.096 mM
Mesocricetus auratus
propionic acid
50% inhibition at 0.17 mM
Mus musculus
propionic acid
50% inhibition at 0.13 mM
Rattus norvegicus
Pyruvic acid
50% inhibition at 0.50 mM
Homo sapiens
Pyruvic acid
50% inhibition at 0.88 mM
Mesocricetus auratus
Pyruvic acid
50% inhibition at 1.5 mM
Mus musculus
Pyruvic acid
50% inhibition at 1.0 mM
Rattus norvegicus
threonic acid
50% inhibition at 0.75 mM
Mesocricetus auratus
threonic acid
50% inhibition at 1.5 mM
Mus musculus
threonic acid
50% inhibition at 1.9 mM
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.001
-
NADP+
pH 7.0, 25C
Homo sapiens
0.002
-
NADP+
pH 7.0, 25C
Cavia porcellus
0.002
-
NADPH
pH 7.0, 25C
Homo sapiens
0.003
-
NADP+
pH 7.0, 25C
Mesocricetus auratus
0.003
-
NADP+
pH 7.0, 25C
Mus musculus
0.003
-
NADP+
pH 7.0, 25C
Rattus norvegicus
0.003
-
NADPH
pH 7.0, 25C
Mesocricetus auratus
0.005
-
NADPH
pH 7.0, 25C
Cavia porcellus
0.005
-
NADPH
pH 7.0, 25C
Mus musculus
0.007
-
NADPH
pH 7.0, 25C
Rattus norvegicus
0.05
-
L-xylulose
pH 7.0, 25C
Cavia porcellus
0.077
-
diacetyl
pH 7.0, 25C
Homo sapiens
0.12
-
NADH
pH 7.0, 25C
Mesocricetus auratus
0.17
-
NADH
pH 7.0, 25C
Homo sapiens
0.2
-
diacetyl
pH 7.0, 25C
Mesocricetus auratus
0.21
-
L-xylulose
pH 7.0, 25C
Homo sapiens
0.22
-
NADH
pH 7.0, 25C
Mus musculus
0.23
-
L-xylulose
pH 7.0, 25C
Rattus norvegicus
0.24
-
L-xylulose
pH 7.0, 25C
Mus musculus
0.26
-
L-xylulose
pH 7.0, 25C
Mesocricetus auratus
0.36
-
NADH
pH 7.0, 25C
Rattus norvegicus
0.52
-
diacetyl
pH 7.0, 25C
Cavia porcellus
0.59
-
D-erythrose
pH 7.0, 25C
Cavia porcellus
0.67
-
diacetyl
pH 7.0, 25C
Mus musculus
0.69
-
NADH
pH 7.0, 25C
Cavia porcellus
0.85
-
NAD+
pH 7.0, 25C
Homo sapiens
0.91
-
NAD+
pH 7.0, 25C
Mesocricetus auratus
0.99
-
NAD+
pH 7.0, 25C
Mus musculus
1.1
-
diacetyl
pH 7.0, 25C
Rattus norvegicus
1.2
-
DL-glyceraldehyde
pH 7.0, 25C
Homo sapiens
1.4
-
DL-glyceraldehyde
pH 7.0, 25C
Cavia porcellus
1.5
-
acetoin
pH 7.0, 25C
Homo sapiens
1.5
-
NAD+
pH 7.0, 25C
Rattus norvegicus
1.6
-
dihydroxyacetone
pH 7.0, 25C
Homo sapiens
1.9
-
D-threose
pH 7.0, 25C
Homo sapiens
2
-
D-threose
pH 7.0, 25C
Cavia porcellus
2
-
L-erythrulose
pH 7.0, 25C
Cavia porcellus
2.4
-
D-erythrose
pH 7.0, 25C
Homo sapiens
2.4
-
D-threose
pH 7.0, 25C
Mus musculus
2.5
-
L-erythrulose
pH 7.0, 25C
Homo sapiens
2.7
-
DL-glyceraldehyde
pH 7.0, 25C
Rattus norvegicus
2.7
-
D-threose
pH 7.0, 25C
Mesocricetus auratus
2.9
-
L-erythrulose
pH 7.0, 25C
Mesocricetus auratus
2.9
-
L-threose
pH 7.0, 25C
Cavia porcellus
3.3
-
acetoin
pH 7.0, 25C
Mesocricetus auratus
3.9
-
D-erythrose
pH 7.0, 25C
Mesocricetus auratus
4
-
D-threose
pH 7.0, 25C
Rattus norvegicus
4.2
-
L-threose
pH 7.0, 25C
Homo sapiens
4.3
-
L-threose
pH 7.0, 25C
Mesocricetus auratus
4.8
-
D-xylulose
pH 7.0, 25C
Homo sapiens
4.8
-
L-erythrulose
pH 7.0, 25C
Mus musculus
5
-
D-ribulose
pH 7.0, 25C
Homo sapiens
5.1
-
DL-glyceraldehyde
pH 7.0, 25C
Mesocricetus auratus
5.5
-
L-erythrulose
pH 7.0, 25C
Rattus norvegicus
5.6
-
L-threose
pH 7.0, 25C
Mus musculus
5.7
-
D-erythrose
pH 7.0, 25C
Mus musculus
5.7
-
D-ribulose
pH 7.0, 25C
Mus musculus
6
-
D-erythrose
pH 7.0, 25C
Rattus norvegicus
6
-
DL-glyceraldehyde
pH 7.0, 25C
Mus musculus
6.3
-
D-ribulose
pH 7.0, 25C
Mesocricetus auratus
6.3
-
D-ribulose
pH 7.0, 25C
Rattus norvegicus
6.9
-
acetoin
pH 7.0, 25C
Rattus norvegicus
7.8
-
D-ribulose
pH 7.0, 25C
Cavia porcellus
8.3
-
L-threose
pH 7.0, 25C
Rattus norvegicus
9
-
acetoin
pH 7.0, 25C
Mus musculus
10
-
xylitol
pH 7.0, 25C
Cavia porcellus
11
-
xylitol
pH 7.0, 25C
Rattus norvegicus
12
-
D-xylulose
pH 7.0, 25C
Mesocricetus auratus
12
-
D-xylulose
pH 7.0, 25C
Mus musculus
13
-
acetoin
pH 7.0, 25C
Cavia porcellus
14
-
D-threitol
pH 7.0, 25C
Cavia porcellus
15
-
xylitol
pH 7.0, 25C
Mus musculus
16
-
D-threitol
pH 7.0, 25C
Rattus norvegicus
18
-
D-threitol
pH 7.0, 25C
Homo sapiens
18
-
D-xylulose
pH 7.0, 25C
Cavia porcellus
18
-
D-xylulose
pH 7.0, 25C
Rattus norvegicus
25
-
xylitol
pH 7.0, 25C
Homo sapiens
34
-
D-threitol
pH 7.0, 25C
Mesocricetus auratus
36
-
dihydroxyacetone
pH 7.0, 25C
Cavia porcellus
37
-
D-threitol
pH 7.0, 25C
Mus musculus
40
-
xylitol
pH 7.0, 25C
Mesocricetus auratus
47
-
dihydroxyacetone
pH 7.0, 25C
Mus musculus
60
-
dihydroxyacetone
pH 7.0, 25C
Mesocricetus auratus
60
-
dihydroxyacetone
pH 7.0, 25C
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Cavia porcellus
5829
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Cavia porcellus
Q920N9
-
-
Homo sapiens
Q7Z4W1
-
-
Mesocricetus auratus
Q91XV4
-
-
Mus musculus
Q91X52
-
-
Rattus norvegicus
Q920P0
-
-
Purification (Commentary)
Commentary
Organism
recombinant enzyme from Escherichia coli, native from liver
Cavia porcellus
recombinant enzyme from Escherichia coli, native from liver
Mesocricetus auratus
Reaction
Reaction
Commentary
Organism
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
Cavia porcellus
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities, it is probably identical with sperm 34 kDa protein P34H and diacetyl reductase, EC 1.1.1.5
Homo sapiens
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
Mesocricetus auratus
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
Mus musculus
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
low expression level
Cavia porcellus
-
brain
low expression level
Homo sapiens
-
brain
low expression level
Mesocricetus auratus
-
brain
low expression level
Mus musculus
-
brain
low expression level
Rattus norvegicus
-
epididymis
-
Cavia porcellus
-
epididymis
-
Homo sapiens
-
epididymis
low expression level
Mesocricetus auratus
-
epididymis
high content
Mus musculus
-
epididymis
low expression level
Rattus norvegicus
-
heart
-
Cavia porcellus
-
heart
low expression level
Homo sapiens
-
heart
low expression level
Mesocricetus auratus
-
heart
low expression level
Mus musculus
-
heart
low expression level
Rattus norvegicus
-
kidney
high content
Cavia porcellus
-
kidney
high content
Homo sapiens
-
kidney
high content
Mesocricetus auratus
-
kidney
high content
Mus musculus
-
kidney
high content
Rattus norvegicus
-
liver
high content
Cavia porcellus
-
liver
high content
Homo sapiens
-
liver
high content
Mesocricetus auratus
-
liver
high content
Rattus norvegicus
-
liver
-
Mus musculus
-
lung
high content
Cavia porcellus
-
lung
low expression level
Homo sapiens
-
lung
low expression level
Mesocricetus auratus
-
lung
-
Mus musculus
-
lung
low expression level
Rattus norvegicus
-
spleen
low expression level
Cavia porcellus
-
spleen
low expression level
Homo sapiens
-
spleen
low expression level
Mesocricetus auratus
-
spleen
low expression level
Mus musculus
-
spleen
-
Rattus norvegicus
-
testis
low expression level
Cavia porcellus
-
testis
low expression level
Homo sapiens
-
testis
low expression level
Mesocricetus auratus
-
testis
low expression level
Mus musculus
-
testis
low expression level
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
143
-
purified native enzyme, L-xylulose reductase activity
Cavia porcellus
642
-
purified native enzyme, L-xylulose reductase activity
Mesocricetus auratus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1,4-dibromo-2,3-butanedione + NAD(P)H
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
656049
Homo sapiens
? + NAD(P)+
-
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
656049
Mus musculus
? + NAD(P)+
-
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
656049
Rattus norvegicus
? + NAD(P)+
-
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
656049
Cavia porcellus
? + NAD(P)+
-
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
656049
Mesocricetus auratus
? + NAD(P)+
-
-
-
r
D-erythrose + NADPH
reductase activity
656049
Homo sapiens
?
-
-
-
r
D-erythrose + NADPH
reductase activity
656049
Mus musculus
?
-
-
-
r
D-erythrose + NADPH
reductase activity
656049
Rattus norvegicus
?
-
-
-
r
D-erythrose + NADPH
reductase activity
656049
Cavia porcellus
?
-
-
-
r
D-erythrose + NADPH
reductase activity
656049
Mesocricetus auratus
?
-
-
-
r
D-ribulose + NADPH
reductase activity
656049
Homo sapiens
D-ribitol + NADP+
-
-
-
r
D-ribulose + NADPH
reductase activity
656049
Mus musculus
D-ribitol + NADP+
-
-
-
r
D-ribulose + NADPH
reductase activity
656049
Rattus norvegicus
D-ribitol + NADP+
-
-
-
r
D-ribulose + NADPH
reductase activity
656049
Cavia porcellus
D-ribitol + NADP+
-
-
-
r
D-ribulose + NADPH
reductase activity
656049
Mesocricetus auratus
D-ribitol + NADP+
-
-
-
r
D-threose + NADPH
reductase activity
656049
Homo sapiens
D-threitol + NADP+
-
-
-
r
D-threose + NADPH
reductase activity
656049
Mus musculus
D-threitol + NADP+
-
-
-
r
D-threose + NADPH
reductase activity
656049
Rattus norvegicus
D-threitol + NADP+
-
-
-
r
D-threose + NADPH
reductase activity
656049
Cavia porcellus
D-threitol + NADP+
-
-
-
r
D-threose + NADPH
reductase activity
656049
Mesocricetus auratus
D-threitol + NADP+
-
-
-
r
D-xylulose + NADH + H+
-
656049
Homo sapiens
D-arabinitol + NAD+
-
-
-
-
D-xylulose + NADPH + H+
reductase activity
656049
Homo sapiens
D-xylitol + NADP+
-
-
-
r
D-xylulose + NADPH + H+
reductase activity
656049
Mus musculus
D-xylitol + NADP+
-
-
-
r
D-xylulose + NADPH + H+
reductase activity
656049
Rattus norvegicus
D-xylitol + NADP+
-
-
-
r
D-xylulose + NADPH + H+
reductase activity
656049
Cavia porcellus
D-xylitol + NADP+
-
-
-
r
D-xylulose + NADPH + H+
reductase activity
656049
Mesocricetus auratus
D-xylitol + NADP+
-
-
-
r
diacetyl + NAD(P)H
-
656049
Mus musculus
acetoin + NAD(P)+
-
-
-
-
diacetyl + NAD(P)H
-
656049
Rattus norvegicus
acetoin + NAD(P)+
-
-
-
-
diacetyl + NAD(P)H
dicarbonyl reductase activity, NADPH is the preferred cofactor
656049
Homo sapiens
acetoin + NAD(P)+
-
-
-
r
diacetyl + NAD(P)H
dicarbonyl reductase activity, NADPH is the preferred cofactor
656049
Mus musculus
acetoin + NAD(P)+
-
-
-
r
diacetyl + NAD(P)H
dicarbonyl reductase activity, NADPH is the preferred cofactor
656049
Rattus norvegicus
acetoin + NAD(P)+
-
-
-
r
diacetyl + NAD(P)H
dicarbonyl reductase activity, NADPH is the preferred cofactor
656049
Cavia porcellus
acetoin + NAD(P)+
-
-
-
r
diacetyl + NAD(P)H
dicarbonyl reductase activity, NADPH is the preferred cofactor
656049
Mesocricetus auratus
acetoin + NAD(P)+
-
-
-
r
DL-glyceraldehyde + NADPH
reductase activity, forward reaction is highly preferred
656049
Homo sapiens
dihydroxyacetone + NADP+
-
-
-
r
DL-glyceraldehyde + NADPH
reductase activity, forward reaction is highly preferred
656049
Mus musculus
dihydroxyacetone + NADP+
-
-
-
r
DL-glyceraldehyde + NADPH
reductase activity, forward reaction is highly preferred
656049
Rattus norvegicus
dihydroxyacetone + NADP+
-
-
-
r
DL-glyceraldehyde + NADPH
reductase activity, forward reaction is highly preferred
656049
Cavia porcellus
dihydroxyacetone + NADP+
-
-
-
r
DL-glyceraldehyde + NADPH
reductase activity, forward reaction is highly preferred
656049
Mesocricetus auratus
dihydroxyacetone + NADP+
-
-
-
r
DL-threitol + NAD+
-
656049
Mus musculus
D-threose + NADH
-
-
-
-
DL-threitol + NAD+
-
656049
Homo sapiens
D-threose + NADH
-
-
-
-
DL-threitol + NAD+
-
656049
Mesocricetus auratus
D-threose + NADH
-
-
-
-
L-erythrulose + NADPH
reductase activity
656049
Homo sapiens
?
-
-
-
r
L-erythrulose + NADPH
reductase activity
656049
Mus musculus
?
-
-
-
r
L-erythrulose + NADPH
reductase activity
656049
Rattus norvegicus
?
-
-
-
r
L-erythrulose + NADPH
reductase activity
656049
Cavia porcellus
?
-
-
-
r
L-erythrulose + NADPH
reductase activity
656049
Mesocricetus auratus
?
-
-
-
r
L-threose + NADPH
reductase activity
656049
Homo sapiens
L-threitol + NADP+
-
-
-
r
L-threose + NADPH
reductase activity
656049
Mus musculus
L-threitol + NADP+
-
-
-
r
L-threose + NADPH
reductase activity
656049
Rattus norvegicus
L-threitol + NADP+
-
-
-
r
L-threose + NADPH
reductase activity
656049
Cavia porcellus
L-threitol + NADP+
-
-
-
r
L-threose + NADPH
reductase activity
656049
Mesocricetus auratus
L-threitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
-
656049
Mus musculus
L-xylitol + NADP+
-
-
-
-
L-xylulose + NADPH + H+
reductase activity
656049
Homo sapiens
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
reductase activity
656049
Mus musculus
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
reductase activity
656049
Rattus norvegicus
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
reductase activity
656049
Cavia porcellus
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
reductase activity
656049
Mesocricetus auratus
L-xylitol + NADP+
-
-
-
r
additional information
substrate specificity for dicarbonyl reductase activity, overview
656049
Homo sapiens
?
-
-
-
-
additional information
substrate specificity for dicarbonyl reductase activity, overview
656049
Mus musculus
?
-
-
-
-
additional information
substrate specificity for dicarbonyl reductase activity, overview
656049
Rattus norvegicus
?
-
-
-
-
additional information
substrate specificity for dicarbonyl reductase activity, overview
656049
Cavia porcellus
?
-
-
-
-
additional information
substrate specificity for dicarbonyl reductase activity, overview
656049
Mesocricetus auratus
?
-
-
-
-
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay at
Cavia porcellus
25
-
assay at
Homo sapiens
25
-
assay at
Mesocricetus auratus
25
-
assay at
Mus musculus
25
-
assay at
Rattus norvegicus
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.1
-
D-xylulose
pH 7.0, 25C
Homo sapiens
0.23
-
dihydroxyacetone
pH 7.0, 25C
Homo sapiens
0.43
-
D-erythrose
pH 7.0, 25C
Homo sapiens
0.48
-
D-threitol
pH 7.0, 25C
Homo sapiens
0.52
-
DL-glyceraldehyde
pH 7.0, 25C
Homo sapiens
0.52
-
D-ribulose
pH 7.0, 25C
Homo sapiens
0.52
-
L-threose
pH 7.0, 25C
Homo sapiens
0.6
-
L-erythrulose
pH 7.0, 25C
Homo sapiens
0.6
-
xylitol
pH 7.0, 25C
Homo sapiens
0.65
-
acetoin
pH 7.0, 25C
Homo sapiens
0.65
-
L-xylulose
pH 7.0, 25C
Homo sapiens
0.65
-
NADP+
pH 7.0, 25C
Homo sapiens
0.82
-
D-threose
pH 7.0, 25C
Homo sapiens
1.5
-
NAD+
pH 7.0, 25C
Homo sapiens
1.5
-
NADPH
pH 7.0, 25C
Homo sapiens
1.6
-
diacetyl
pH 7.0, 25C
Homo sapiens
2
8
D-erythrose
pH 7.0, 25C
Cavia porcellus
2
8
D-threose
pH 7.0, 25C
Rattus norvegicus
2
8
NADH
pH 7.0, 25C
Mesocricetus auratus
2
8
xylitol
pH 7.0, 25C
Mesocricetus auratus
3
6
L-xylulose
pH 7.0, 25C
Mesocricetus auratus
3
-
acetoin
pH 7.0, 25C
Mus musculus
3.3
-
dihydroxyacetone
pH 7.0, 25C
Mus musculus
3.8
-
dihydroxyacetone
pH 7.0, 25C
Cavia porcellus
3.8
-
NADH
pH 7.0, 25C
Homo sapiens
5.1
-
dihydroxyacetone
pH 7.0, 25C
Rattus norvegicus
6.9
-
acetoin
pH 7.0, 25C
Cavia porcellus
6.9
-
acetoin
pH 7.0, 25C
Mesocricetus auratus
6.9
-
acetoin
pH 7.0, 25C
Rattus norvegicus
6.9
-
D-xylulose
pH 7.0, 25C
Mesocricetus auratus
7.4
-
D-xylulose
pH 7.0, 25C
Mus musculus
7.8
-
D-ribulose
pH 7.0, 25C
Cavia porcellus
8.7
-
dihydroxyacetone
pH 7.0, 25C
Mesocricetus auratus
10
-
NADP+
pH 7.0, 25C
Rattus norvegicus
10
-
xylitol
pH 7.0, 25C
Rattus norvegicus
12
-
D-threitol
pH 7.0, 25C
Rattus norvegicus
15
-
D-threitol
pH 7.0, 25C
Cavia porcellus
15
-
NADP+
pH 7.0, 25C
Mus musculus
16
-
D-threitol
pH 7.0, 25C
Mesocricetus auratus
16
-
D-threitol
pH 7.0, 25C
Mus musculus
16
-
L-threose
pH 7.0, 25C
Mus musculus
16
-
L-threose
pH 7.0, 25C
Rattus norvegicus
17
-
xylitol
pH 7.0, 25C
Mus musculus
18
-
D-erythrose
pH 7.0, 25C
Mus musculus
18
-
D-erythrose
pH 7.0, 25C
Rattus norvegicus
18
-
D-xylulose
pH 7.0, 25C
Rattus norvegicus
19
-
D-ribulose
pH 7.0, 25C
Rattus norvegicus
19
-
D-xylulose
pH 7.0, 25C
Cavia porcellus
20
-
DL-glyceraldehyde
pH 7.0, 25C
Cavia porcellus
20
-
xylitol
pH 7.0, 25C
Cavia porcellus
21
-
DL-glyceraldehyde
pH 7.0, 25C
Rattus norvegicus
22
-
DL-glyceraldehyde
pH 7.0, 25C
Mesocricetus auratus
23
-
D-erythrose
pH 7.0, 25C
Mesocricetus auratus
23
-
D-threose
pH 7.0, 25C
Mus musculus
23
-
L-erythrulose
pH 7.0, 25C
Mus musculus
23
-
L-threose
pH 7.0, 25C
Mesocricetus auratus
23
-
NADH
pH 7.0, 25C
Rattus norvegicus
23
-
NADP+
pH 7.0, 25C
Cavia porcellus
24
-
diacetyl
pH 7.0, 25C
Cavia porcellus
24
-
DL-glyceraldehyde
pH 7.0, 25C
Mus musculus
24
-
L-erythrulose
pH 7.0, 25C
Cavia porcellus
25
-
diacetyl
pH 7.0, 25C
Rattus norvegicus
25
-
L-erythrulose
pH 7.0, 25C
Mesocricetus auratus
25
-
L-erythrulose
pH 7.0, 25C
Rattus norvegicus
25
-
NADPH
pH 7.0, 25C
Rattus norvegicus
26
-
D-ribulose
pH 7.0, 25C
Mus musculus
26
-
NADP+
pH 7.0, 25C
Mesocricetus auratus
26
-
NADPH
pH 7.0, 25C
Cavia porcellus
27
-
L-threose
pH 7.0, 25C
Cavia porcellus
27
-
NADPH
pH 7.0, 25C
Mesocricetus auratus
30
-
diacetyl
pH 7.0, 25C
Mesocricetus auratus
31
-
D-ribulose
pH 7.0, 25C
Mesocricetus auratus
31
-
D-threose
pH 7.0, 25C
Mesocricetus auratus
32
-
D-threose
pH 7.0, 25C
Cavia porcellus
34
-
NADPH
pH 7.0, 25C
Mus musculus
37
-
L-xylulose
pH 7.0, 25C
Cavia porcellus
37
-
L-xylulose
pH 7.0, 25C
Mus musculus
39
-
L-xylulose
pH 7.0, 25C
Rattus norvegicus
41
-
diacetyl
pH 7.0, 25C
Mus musculus
41
-
NAD+
pH 7.0, 25C
Rattus norvegicus
41
-
NADH
pH 7.0, 25C
Mus musculus
44
-
NAD+
pH 7.0, 25C
Mesocricetus auratus
55
-
NAD+
pH 7.0, 25C
Mus musculus
76
-
NADH
pH 7.0, 25C
Cavia porcellus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Cavia porcellus
7
-
assay at
Homo sapiens
7
-
assay at
Mesocricetus auratus
7
-
assay at
Mus musculus
7
-
assay at
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Cavia porcellus
NAD+
-
Homo sapiens
NAD+
-
Mesocricetus auratus
NAD+
-
Mus musculus
NAD+
-
Rattus norvegicus
NADH
-
Cavia porcellus
NADH
-
Homo sapiens
NADH
-
Mesocricetus auratus
NADH
-
Mus musculus
NADH
-
Rattus norvegicus
NADP+
preferred cofactor, reverse reaction
Cavia porcellus
NADP+
preferred cofactor, reverse reaction
Homo sapiens
NADP+
preferred cofactor, reverse reaction
Mesocricetus auratus
NADP+
preferred cofactor, reverse reaction
Mus musculus
NADP+
preferred cofactor, reverse reaction
Rattus norvegicus
NADPH
preferred cofactor, forward reaction
Cavia porcellus
NADPH
preferred cofactor, forward reaction
Homo sapiens
NADPH
preferred cofactor, forward reaction
Mesocricetus auratus
NADPH
preferred cofactor, forward reaction
Mus musculus
NADPH
preferred cofactor, forward reaction
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
DNA sequence determination and analysis, expression in Escherichia coli strain BL21(DE3)
Cavia porcellus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Cavia porcellus
NAD+
-
Homo sapiens
NAD+
-
Mesocricetus auratus
NAD+
-
Mus musculus
NAD+
-
Rattus norvegicus
NADH
-
Cavia porcellus
NADH
-
Homo sapiens
NADH
-
Mesocricetus auratus
NADH
-
Mus musculus
NADH
-
Rattus norvegicus
NADP+
preferred cofactor, reverse reaction
Cavia porcellus
NADP+
preferred cofactor, reverse reaction
Homo sapiens
NADP+
preferred cofactor, reverse reaction
Mesocricetus auratus
NADP+
preferred cofactor, reverse reaction
Mus musculus
NADP+
preferred cofactor, reverse reaction
Rattus norvegicus
NADPH
preferred cofactor, forward reaction
Cavia porcellus
NADPH
preferred cofactor, forward reaction
Homo sapiens
NADPH
preferred cofactor, forward reaction
Mesocricetus auratus
NADPH
preferred cofactor, forward reaction
Mus musculus
NADPH
preferred cofactor, forward reaction
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
3-hydroxybutyric acid
50% inhibition at 1.1 mM
Homo sapiens
3-hydroxybutyric acid
50% inhibition at 1.0 mM
Mesocricetus auratus
3-hydroxybutyric acid
50% inhibition at 2.0 mM
Rattus norvegicus
acetoacetic acid
50% inhibition at 0.63 mM
Homo sapiens
acetoacetic acid
50% inhibition at 1.8 mM
Mesocricetus auratus
acetoacetic acid
50% inhibition at 2.5 mM
Rattus norvegicus
heptanoic acid
50% inhibition at 0.38 mM
Homo sapiens
heptanoic acid
50% inhibition at 1.4 mM
Mesocricetus auratus
heptanoic acid
50% inhibition at 2.0 mM
Mus musculus
heptanoic acid
50% inhibition at 2.5 mM
Rattus norvegicus
hexanoic acid
50% inhibition at 0.10 mM
Homo sapiens
hexanoic acid
50% inhibition at 0.40 mM
Mesocricetus auratus
hexanoic acid
50% inhibition at 1.1 mM
Mus musculus
hexanoic acid
50% inhibition at 0.42 mM
Rattus norvegicus
additional information
acetic acid, threonic acid, and octanoic acid are poor inhibitors
Homo sapiens
additional information
acetic acid is a poor inhibitor
Mesocricetus auratus
additional information
acetic acid, acetoacetic acid, 3-OH-butyric acid, and octanoic acid are poor inhibitors
Mus musculus
additional information
acetic acid, oxaloacetic acid, and octanoic acid are poor inhibitors
Rattus norvegicus
n-butyric acid
50% inhibition at 0.064 mM
Homo sapiens
n-butyric acid
50% inhibition at 0.026 mM
Mesocricetus auratus
n-butyric acid
50% inhibition at 0.05 mM
Mus musculus
n-butyric acid
50% inhibition at 0.052 mM
Rattus norvegicus
Octanoic acid
50% inhibition at 2.5 mM
Mesocricetus auratus
oxaloacetic acid
50% inhibition at 0.91 mM
Homo sapiens
oxaloacetic acid
50% inhibition at 2.5 mM
Mesocricetus auratus
oxaloacetic acid
50% inhibition at 2.5 mM
Mus musculus
pentanoic acid
50% inhibition at 0.15 mM
Homo sapiens
pentanoic acid
50% inhibition at 0.20 mM
Mesocricetus auratus
pentanoic acid
50% inhibition at 0.38 mM
Mus musculus
pentanoic acid
50% inhibition at 0.5 mM
Rattus norvegicus
propionic acid
50% inhibition at 0.38 mM
Homo sapiens
propionic acid
50% inhibition at 0.096 mM
Mesocricetus auratus
propionic acid
50% inhibition at 0.17 mM
Mus musculus
propionic acid
50% inhibition at 0.13 mM
Rattus norvegicus
Pyruvic acid
50% inhibition at 0.50 mM
Homo sapiens
Pyruvic acid
50% inhibition at 0.88 mM
Mesocricetus auratus
Pyruvic acid
50% inhibition at 1.5 mM
Mus musculus
Pyruvic acid
50% inhibition at 1.0 mM
Rattus norvegicus
threonic acid
50% inhibition at 0.75 mM
Mesocricetus auratus
threonic acid
50% inhibition at 1.5 mM
Mus musculus
threonic acid
50% inhibition at 1.9 mM
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.001
-
NADP+
pH 7.0, 25C
Homo sapiens
0.002
-
NADP+
pH 7.0, 25C
Cavia porcellus
0.002
-
NADPH
pH 7.0, 25C
Homo sapiens
0.003
-
NADP+
pH 7.0, 25C
Mesocricetus auratus
0.003
-
NADP+
pH 7.0, 25C
Mus musculus
0.003
-
NADP+
pH 7.0, 25C
Rattus norvegicus
0.003
-
NADPH
pH 7.0, 25C
Mesocricetus auratus
0.005
-
NADPH
pH 7.0, 25C
Cavia porcellus
0.005
-
NADPH
pH 7.0, 25C
Mus musculus
0.007
-
NADPH
pH 7.0, 25C
Rattus norvegicus
0.05
-
L-xylulose
pH 7.0, 25C
Cavia porcellus
0.077
-
diacetyl
pH 7.0, 25C
Homo sapiens
0.12
-
NADH
pH 7.0, 25C
Mesocricetus auratus
0.17
-
NADH
pH 7.0, 25C
Homo sapiens
0.2
-
diacetyl
pH 7.0, 25C
Mesocricetus auratus
0.21
-
L-xylulose
pH 7.0, 25C
Homo sapiens
0.22
-
NADH
pH 7.0, 25C
Mus musculus
0.23
-
L-xylulose
pH 7.0, 25C
Rattus norvegicus
0.24
-
L-xylulose
pH 7.0, 25C
Mus musculus
0.26
-
L-xylulose
pH 7.0, 25C
Mesocricetus auratus
0.36
-
NADH
pH 7.0, 25C
Rattus norvegicus
0.52
-
diacetyl
pH 7.0, 25C
Cavia porcellus
0.59
-
D-erythrose
pH 7.0, 25C
Cavia porcellus
0.67
-
diacetyl
pH 7.0, 25C
Mus musculus
0.69
-
NADH
pH 7.0, 25C
Cavia porcellus
0.85
-
NAD+
pH 7.0, 25C
Homo sapiens
0.91
-
NAD+
pH 7.0, 25C
Mesocricetus auratus
0.99
-
NAD+
pH 7.0, 25C
Mus musculus
1.1
-
diacetyl
pH 7.0, 25C
Rattus norvegicus
1.2
-
DL-glyceraldehyde
pH 7.0, 25C
Homo sapiens
1.4
-
DL-glyceraldehyde
pH 7.0, 25C
Cavia porcellus
1.5
-
acetoin
pH 7.0, 25C
Homo sapiens
1.5
-
NAD+
pH 7.0, 25C
Rattus norvegicus
1.6
-
dihydroxyacetone
pH 7.0, 25C
Homo sapiens
1.9
-
D-threose
pH 7.0, 25C
Homo sapiens
2
-
D-threose
pH 7.0, 25C
Cavia porcellus
2
-
L-erythrulose
pH 7.0, 25C
Cavia porcellus
2.4
-
D-erythrose
pH 7.0, 25C
Homo sapiens
2.4
-
D-threose
pH 7.0, 25C
Mus musculus
2.5
-
L-erythrulose
pH 7.0, 25C
Homo sapiens
2.7
-
DL-glyceraldehyde
pH 7.0, 25C
Rattus norvegicus
2.7
-
D-threose
pH 7.0, 25C
Mesocricetus auratus
2.9
-
L-erythrulose
pH 7.0, 25C
Mesocricetus auratus
2.9
-
L-threose
pH 7.0, 25C
Cavia porcellus
3.3
-
acetoin
pH 7.0, 25C
Mesocricetus auratus
3.9
-
D-erythrose
pH 7.0, 25C
Mesocricetus auratus
4
-
D-threose
pH 7.0, 25C
Rattus norvegicus
4.2
-
L-threose
pH 7.0, 25C
Homo sapiens
4.3
-
L-threose
pH 7.0, 25C
Mesocricetus auratus
4.8
-
D-xylulose
pH 7.0, 25C
Homo sapiens
4.8
-
L-erythrulose
pH 7.0, 25C
Mus musculus
5
-
D-ribulose
pH 7.0, 25C
Homo sapiens
5.1
-
DL-glyceraldehyde
pH 7.0, 25C
Mesocricetus auratus
5.5
-
L-erythrulose
pH 7.0, 25C
Rattus norvegicus
5.6
-
L-threose
pH 7.0, 25C
Mus musculus
5.7
-
D-erythrose
pH 7.0, 25C
Mus musculus
5.7
-
D-ribulose
pH 7.0, 25C
Mus musculus
6
-
D-erythrose
pH 7.0, 25C
Rattus norvegicus
6
-
DL-glyceraldehyde
pH 7.0, 25C
Mus musculus
6.3
-
D-ribulose
pH 7.0, 25C
Mesocricetus auratus
6.3
-
D-ribulose
pH 7.0, 25C
Rattus norvegicus
6.9
-
acetoin
pH 7.0, 25C
Rattus norvegicus
7.8
-
D-ribulose
pH 7.0, 25C
Cavia porcellus
8.3
-
L-threose
pH 7.0, 25C
Rattus norvegicus
9
-
acetoin
pH 7.0, 25C
Mus musculus
10
-
xylitol
pH 7.0, 25C
Cavia porcellus
11
-
xylitol
pH 7.0, 25C
Rattus norvegicus
12
-
D-xylulose
pH 7.0, 25C
Mesocricetus auratus
12
-
D-xylulose
pH 7.0, 25C
Mus musculus
13
-
acetoin
pH 7.0, 25C
Cavia porcellus
14
-
D-threitol
pH 7.0, 25C
Cavia porcellus
15
-
xylitol
pH 7.0, 25C
Mus musculus
16
-
D-threitol
pH 7.0, 25C
Rattus norvegicus
18
-
D-threitol
pH 7.0, 25C
Homo sapiens
18
-
D-xylulose
pH 7.0, 25C
Cavia porcellus
18
-
D-xylulose
pH 7.0, 25C
Rattus norvegicus
25
-
xylitol
pH 7.0, 25C
Homo sapiens
34
-
D-threitol
pH 7.0, 25C
Mesocricetus auratus
36
-
dihydroxyacetone
pH 7.0, 25C
Cavia porcellus
37
-
D-threitol
pH 7.0, 25C
Mus musculus
40
-
xylitol
pH 7.0, 25C
Mesocricetus auratus
47
-
dihydroxyacetone
pH 7.0, 25C
Mus musculus
60
-
dihydroxyacetone
pH 7.0, 25C
Mesocricetus auratus
60
-
dihydroxyacetone
pH 7.0, 25C
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Cavia porcellus
5829
-
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant enzyme from Escherichia coli, native from liver
Cavia porcellus
recombinant enzyme from Escherichia coli, native from liver
Mesocricetus auratus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
low expression level
Cavia porcellus
-
brain
low expression level
Homo sapiens
-
brain
low expression level
Mesocricetus auratus
-
brain
low expression level
Mus musculus
-
brain
low expression level
Rattus norvegicus
-
epididymis
-
Cavia porcellus
-
epididymis
-
Homo sapiens
-
epididymis
low expression level
Mesocricetus auratus
-
epididymis
high content
Mus musculus
-
epididymis
low expression level
Rattus norvegicus
-
heart
-
Cavia porcellus
-
heart
low expression level
Homo sapiens
-
heart
low expression level
Mesocricetus auratus
-
heart
low expression level
Mus musculus
-
heart
low expression level
Rattus norvegicus
-
kidney
high content
Cavia porcellus
-
kidney
high content
Homo sapiens
-
kidney
high content
Mesocricetus auratus
-
kidney
high content
Mus musculus
-
kidney
high content
Rattus norvegicus
-
liver
high content
Cavia porcellus
-
liver
high content
Homo sapiens
-
liver
high content
Mesocricetus auratus
-
liver
-
Mus musculus
-
liver
high content
Rattus norvegicus
-
lung
high content
Cavia porcellus
-
lung
low expression level
Homo sapiens
-
lung
low expression level
Mesocricetus auratus
-
lung
-
Mus musculus
-
lung
low expression level
Rattus norvegicus
-
spleen
low expression level
Cavia porcellus
-
spleen
low expression level
Homo sapiens
-
spleen
low expression level
Mesocricetus auratus
-
spleen
low expression level
Mus musculus
-
spleen
-
Rattus norvegicus
-
testis
low expression level
Cavia porcellus
-
testis
low expression level
Homo sapiens
-
testis
low expression level
Mesocricetus auratus
-
testis
low expression level
Mus musculus
-
testis
low expression level
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
143
-
purified native enzyme, L-xylulose reductase activity
Cavia porcellus
642
-
purified native enzyme, L-xylulose reductase activity
Mesocricetus auratus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1,4-dibromo-2,3-butanedione + NAD(P)H
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
656049
Homo sapiens
? + NAD(P)+
-
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
656049
Mus musculus
? + NAD(P)+
-
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
656049
Rattus norvegicus
? + NAD(P)+
-
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
656049
Cavia porcellus
? + NAD(P)+
-
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
656049
Mesocricetus auratus
? + NAD(P)+
-
-
-
r
D-erythrose + NADPH
reductase activity
656049
Homo sapiens
?
-
-
-
r
D-erythrose + NADPH
reductase activity
656049
Mus musculus
?
-
-
-
r
D-erythrose + NADPH
reductase activity
656049
Rattus norvegicus
?
-
-
-
r
D-erythrose + NADPH
reductase activity
656049
Cavia porcellus
?
-
-
-
r
D-erythrose + NADPH
reductase activity
656049
Mesocricetus auratus
?
-
-
-
r
D-ribulose + NADPH
reductase activity
656049
Homo sapiens
D-ribitol + NADP+
-
-
-
r
D-ribulose + NADPH
reductase activity
656049
Mus musculus
D-ribitol + NADP+
-
-
-
r
D-ribulose + NADPH
reductase activity
656049
Rattus norvegicus
D-ribitol + NADP+
-
-
-
r
D-ribulose + NADPH
reductase activity
656049
Cavia porcellus
D-ribitol + NADP+
-
-
-
r
D-ribulose + NADPH
reductase activity
656049
Mesocricetus auratus
D-ribitol + NADP+
-
-
-
r
D-threose + NADPH
reductase activity
656049
Homo sapiens
D-threitol + NADP+
-
-
-
r
D-threose + NADPH
reductase activity
656049
Mus musculus
D-threitol + NADP+
-
-
-
r
D-threose + NADPH
reductase activity
656049
Rattus norvegicus
D-threitol + NADP+
-
-
-
r
D-threose + NADPH
reductase activity
656049
Cavia porcellus
D-threitol + NADP+
-
-
-
r
D-threose + NADPH
reductase activity
656049
Mesocricetus auratus
D-threitol + NADP+
-
-
-
r
D-xylulose + NADH + H+
-
656049
Homo sapiens
D-arabinitol + NAD+
-
-
-
-
D-xylulose + NADPH + H+
reductase activity
656049
Homo sapiens
D-xylitol + NADP+
-
-
-
r
D-xylulose + NADPH + H+
reductase activity
656049
Mus musculus
D-xylitol + NADP+
-
-
-
r
D-xylulose + NADPH + H+
reductase activity
656049
Rattus norvegicus
D-xylitol + NADP+
-
-
-
r
D-xylulose + NADPH + H+
reductase activity
656049
Cavia porcellus
D-xylitol + NADP+
-
-
-
r
D-xylulose + NADPH + H+
reductase activity
656049
Mesocricetus auratus
D-xylitol + NADP+
-
-
-
r
diacetyl + NAD(P)H
-
656049
Mus musculus
acetoin + NAD(P)+
-
-
-
-
diacetyl + NAD(P)H
-
656049
Rattus norvegicus
acetoin + NAD(P)+
-
-
-
-
diacetyl + NAD(P)H
dicarbonyl reductase activity, NADPH is the preferred cofactor
656049
Homo sapiens
acetoin + NAD(P)+
-
-
-
r
diacetyl + NAD(P)H
dicarbonyl reductase activity, NADPH is the preferred cofactor
656049
Mus musculus
acetoin + NAD(P)+
-
-
-
r
diacetyl + NAD(P)H
dicarbonyl reductase activity, NADPH is the preferred cofactor
656049
Rattus norvegicus
acetoin + NAD(P)+
-
-
-
r
diacetyl + NAD(P)H
dicarbonyl reductase activity, NADPH is the preferred cofactor
656049
Cavia porcellus
acetoin + NAD(P)+
-
-
-
r
diacetyl + NAD(P)H
dicarbonyl reductase activity, NADPH is the preferred cofactor
656049
Mesocricetus auratus
acetoin + NAD(P)+
-
-
-
r
DL-glyceraldehyde + NADPH
reductase activity, forward reaction is highly preferred
656049
Homo sapiens
dihydroxyacetone + NADP+
-
-
-
r
DL-glyceraldehyde + NADPH
reductase activity, forward reaction is highly preferred
656049
Mus musculus
dihydroxyacetone + NADP+
-
-
-
r
DL-glyceraldehyde + NADPH
reductase activity, forward reaction is highly preferred
656049
Rattus norvegicus
dihydroxyacetone + NADP+
-
-
-
r
DL-glyceraldehyde + NADPH
reductase activity, forward reaction is highly preferred
656049
Cavia porcellus
dihydroxyacetone + NADP+
-
-
-
r
DL-glyceraldehyde + NADPH
reductase activity, forward reaction is highly preferred
656049
Mesocricetus auratus
dihydroxyacetone + NADP+
-
-
-
r
DL-threitol + NAD+
-
656049
Mus musculus
D-threose + NADH
-
-
-
-
DL-threitol + NAD+
-
656049
Homo sapiens
D-threose + NADH
-
-
-
-
DL-threitol + NAD+
-
656049
Mesocricetus auratus
D-threose + NADH
-
-
-
-
L-erythrulose + NADPH
reductase activity
656049
Homo sapiens
?
-
-
-
r
L-erythrulose + NADPH
reductase activity
656049
Mus musculus
?
-
-
-
r
L-erythrulose + NADPH
reductase activity
656049
Rattus norvegicus
?
-
-
-
r
L-erythrulose + NADPH
reductase activity
656049
Cavia porcellus
?
-
-
-
r
L-erythrulose + NADPH
reductase activity
656049
Mesocricetus auratus
?
-
-
-
r
L-threose + NADPH
reductase activity
656049
Homo sapiens
L-threitol + NADP+
-
-
-
r
L-threose + NADPH
reductase activity
656049
Mus musculus
L-threitol + NADP+
-
-
-
r
L-threose + NADPH
reductase activity
656049
Rattus norvegicus
L-threitol + NADP+
-
-
-
r
L-threose + NADPH
reductase activity
656049
Cavia porcellus
L-threitol + NADP+
-
-
-
r
L-threose + NADPH
reductase activity
656049
Mesocricetus auratus
L-threitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
-
656049
Mus musculus
L-xylitol + NADP+
-
-
-
-
L-xylulose + NADPH + H+
reductase activity
656049
Homo sapiens
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
reductase activity
656049
Mus musculus
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
reductase activity
656049
Rattus norvegicus
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
reductase activity
656049
Cavia porcellus
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
reductase activity
656049
Mesocricetus auratus
L-xylitol + NADP+
-
-
-
r
additional information
substrate specificity for dicarbonyl reductase activity, overview
656049
Homo sapiens
?
-
-
-
-
additional information
substrate specificity for dicarbonyl reductase activity, overview
656049
Mus musculus
?
-
-
-
-
additional information
substrate specificity for dicarbonyl reductase activity, overview
656049
Rattus norvegicus
?
-
-
-
-
additional information
substrate specificity for dicarbonyl reductase activity, overview
656049
Cavia porcellus
?
-
-
-
-
additional information
substrate specificity for dicarbonyl reductase activity, overview
656049
Mesocricetus auratus
?
-
-
-
-
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay at
Cavia porcellus
25
-
assay at
Homo sapiens
25
-
assay at
Mesocricetus auratus
25
-
assay at
Mus musculus
25
-
assay at
Rattus norvegicus
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.1
-
D-xylulose
pH 7.0, 25C
Homo sapiens
0.23
-
dihydroxyacetone
pH 7.0, 25C
Homo sapiens
0.43
-
D-erythrose
pH 7.0, 25C
Homo sapiens
0.48
-
D-threitol
pH 7.0, 25C
Homo sapiens
0.52
-
DL-glyceraldehyde
pH 7.0, 25C
Homo sapiens
0.52
-
D-ribulose
pH 7.0, 25C
Homo sapiens
0.52
-
L-threose
pH 7.0, 25C
Homo sapiens
0.6
-
L-erythrulose
pH 7.0, 25C
Homo sapiens
0.6
-
xylitol
pH 7.0, 25C
Homo sapiens
0.65
-
acetoin
pH 7.0, 25C
Homo sapiens
0.65
-
L-xylulose
pH 7.0, 25C
Homo sapiens
0.65
-
NADP+
pH 7.0, 25C
Homo sapiens
0.82
-
D-threose
pH 7.0, 25C
Homo sapiens
1.5
-
NAD+
pH 7.0, 25C
Homo sapiens
1.5
-
NADPH
pH 7.0, 25C
Homo sapiens
1.6
-
diacetyl
pH 7.0, 25C
Homo sapiens
2
8
D-erythrose
pH 7.0, 25C
Cavia porcellus
2
8
D-threose
pH 7.0, 25C
Rattus norvegicus
2
8
NADH
pH 7.0, 25C
Mesocricetus auratus
2
8
xylitol
pH 7.0, 25C
Mesocricetus auratus
3
6
L-xylulose
pH 7.0, 25C
Mesocricetus auratus
3
-
acetoin
pH 7.0, 25C
Mus musculus
3.3
-
dihydroxyacetone
pH 7.0, 25C
Mus musculus
3.8
-
dihydroxyacetone
pH 7.0, 25C
Cavia porcellus
3.8
-
NADH
pH 7.0, 25C
Homo sapiens
5.1
-
dihydroxyacetone
pH 7.0, 25C
Rattus norvegicus
6.9
-
acetoin
pH 7.0, 25C
Cavia porcellus
6.9
-
acetoin
pH 7.0, 25C
Mesocricetus auratus
6.9
-
acetoin
pH 7.0, 25C
Rattus norvegicus
6.9
-
D-xylulose
pH 7.0, 25C
Mesocricetus auratus
7.4
-
D-xylulose
pH 7.0, 25C
Mus musculus
7.8
-
D-ribulose
pH 7.0, 25C
Cavia porcellus
8.7
-
dihydroxyacetone
pH 7.0, 25C
Mesocricetus auratus
10
-
NADP+
pH 7.0, 25C
Rattus norvegicus
10
-
xylitol
pH 7.0, 25C
Rattus norvegicus
12
-
D-threitol
pH 7.0, 25C
Rattus norvegicus
15
-
D-threitol
pH 7.0, 25C
Cavia porcellus
15
-
NADP+
pH 7.0, 25C
Mus musculus
16
-
D-threitol
pH 7.0, 25C
Mesocricetus auratus
16
-
D-threitol
pH 7.0, 25C
Mus musculus
16
-
L-threose
pH 7.0, 25C
Mus musculus
16
-
L-threose
pH 7.0, 25C
Rattus norvegicus
17
-
xylitol
pH 7.0, 25C
Mus musculus
18
-
D-erythrose
pH 7.0, 25C
Mus musculus
18
-
D-erythrose
pH 7.0, 25C
Rattus norvegicus
18
-
D-xylulose
pH 7.0, 25C
Rattus norvegicus
19
-
D-ribulose
pH 7.0, 25C
Rattus norvegicus
19
-
D-xylulose
pH 7.0, 25C
Cavia porcellus
20
-
DL-glyceraldehyde
pH 7.0, 25C
Cavia porcellus
20
-
xylitol
pH 7.0, 25C
Cavia porcellus
21
-
DL-glyceraldehyde
pH 7.0, 25C
Rattus norvegicus
22
-
DL-glyceraldehyde
pH 7.0, 25C
Mesocricetus auratus
23
-
D-erythrose
pH 7.0, 25C
Mesocricetus auratus
23
-
D-threose
pH 7.0, 25C
Mus musculus
23
-
L-erythrulose
pH 7.0, 25C
Mus musculus
23
-
L-threose
pH 7.0, 25C
Mesocricetus auratus
23
-
NADH
pH 7.0, 25C
Rattus norvegicus
23
-
NADP+
pH 7.0, 25C
Cavia porcellus
24
-
diacetyl
pH 7.0, 25C
Cavia porcellus
24
-
DL-glyceraldehyde
pH 7.0, 25C
Mus musculus
24
-
L-erythrulose
pH 7.0, 25C
Cavia porcellus
25
-
diacetyl
pH 7.0, 25C
Rattus norvegicus
25
-
L-erythrulose
pH 7.0, 25C
Mesocricetus auratus
25
-
L-erythrulose
pH 7.0, 25C
Rattus norvegicus
25
-
NADPH
pH 7.0, 25C
Rattus norvegicus
26
-
D-ribulose
pH 7.0, 25C
Mus musculus
26
-
NADP+
pH 7.0, 25C
Mesocricetus auratus
26
-
NADPH
pH 7.0, 25C
Cavia porcellus
27
-
L-threose
pH 7.0, 25C
Cavia porcellus
27
-
NADPH
pH 7.0, 25C
Mesocricetus auratus
30
-
diacetyl
pH 7.0, 25C
Mesocricetus auratus
31
-
D-ribulose
pH 7.0, 25C
Mesocricetus auratus
31
-
D-threose
pH 7.0, 25C
Mesocricetus auratus
32
-
D-threose
pH 7.0, 25C
Cavia porcellus
34
-
NADPH
pH 7.0, 25C
Mus musculus
37
-
L-xylulose
pH 7.0, 25C
Cavia porcellus
37
-
L-xylulose
pH 7.0, 25C
Mus musculus
39
-
L-xylulose
pH 7.0, 25C
Rattus norvegicus
41
-
diacetyl
pH 7.0, 25C
Mus musculus
41
-
NAD+
pH 7.0, 25C
Rattus norvegicus
41
-
NADH
pH 7.0, 25C
Mus musculus
44
-
NAD+
pH 7.0, 25C
Mesocricetus auratus
55
-
NAD+
pH 7.0, 25C
Mus musculus
76
-
NADH
pH 7.0, 25C
Cavia porcellus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Cavia porcellus
7
-
assay at
Homo sapiens
7
-
assay at
Mesocricetus auratus
7
-
assay at
Mus musculus
7
-
assay at
Rattus norvegicus
Other publictions for EC 1.1.1.10
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
721689
Metz
A novel L-xylulose reductase e ...
Trichoderma reesei, Trichoderma reesei QM9414
Biochemistry
52
2453-2460
2013
-
-
1
-
1
-
-
5
-
-
1
2
-
4
-
-
1
-
-
-
-
-
13
1
-
-
-
5
2
-
-
2
-
-
-
-
-
1
2
-
1
-
-
-
-
5
-
-
1
2
-
-
-
1
-
-
-
-
13
1
-
-
-
5
2
-
-
-
1
4
4
1
-
-
722271
Son
DHS-21, a dicarbonyl/L-xylulos ...
Caenorhabditis elegans
FEBS Lett.
585
1310-1316
2011
-
-
1
-
1
-
-
6
1
-
-
2
-
2
-
-
-
-
-
5
-
-
8
-
-
-
-
6
1
-
-
2
-
-
-
-
-
1
2
-
1
-
-
-
-
6
1
-
-
2
-
-
-
-
-
5
-
-
8
-
-
-
-
6
1
-
-
-
1
3
3
1
6
6
712023
Mojzita
The true L-xylulose reductase ...
Aspergillus niger
FEBS Lett.
584
3540-3544
2010
-
-
1
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
695778
Matsushika
Efficient bioethanol productio ...
Scheffersomyces stipitis
Appl. Environ. Microbiol.
75
3818-3822
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695829
Hou
Impact of overexpressing NADH ...
Scheffersomyces stipitis
Appl. Microbiol. Biotechnol.
82
909-919
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
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