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EC Number
Protein Variants
Commentary
Reference
3.4.21.122
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TMPRSS2 mutants lacking exon 4 or exon 5 are devoid of enzymatic activity
754531
3.4.21.122
R255Q
mutation results in a loss of autoproteolytic cleavage. The mutant enzyme appeared as a single protein species with an apparent molecular weight of 70000, the cleaved 32000 MW protease domain is not detected
764399
3.4.21.122
S441A
inactive
753762
,
754533
3.4.21.122
S441A
mutation results in a loss of autoproteolytic cleavage. The mutant enzyme appeared as a single protein species with an apparent molecular weight of 70000, the cleaved 32000 MW protease domain is not detected
764399
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