EC Number   |
Protein Variants |
Reference |
|---|
   2.7.11.31 | D157A |
a dominant negative mutant of AMPKalpha1 |
690725 |
| 2.7.11.31 | D157A |
AMPKalpha2 mutant, expression of a dominant-negative AMPK alpha results in a decreased ATP level and significantly compromised survival in hypoxia |
690726 |
| 2.7.11.31 | D157A |
site-directed mutagenesis |
644983 |
| 2.7.11.31 | D329K |
catalytic kinase domain/autoinhibitory domain mutant, shows enhanced specific activity |
705884 |
| 2.7.11.31 | E344K |
mutation in the autoinhibitory domain, disruption of the hydrophilic interactions, yields a modest but marked increase in basal activity |
705884 |
| 2.7.11.31 | F300E |
catalytic kinase domain/autoinhibitory domain mutant, shows enhanced specific activity |
705884 |
| 2.7.11.31 | H150R |
constitutively active AMPKgamma1 mutant, stimulates the concentration-dependent increase of substrate phosphorylation |
704688 |
| 2.7.11.31 | H379A |
site-directed mutagenesis, mutation of beta subunit Gal83 with little effect on Gal83 function |
-, 740280 |
| 2.7.11.31 | H380A |
site-directed mutagenesis, mutation of beta subunit Sip2, mutation does not affect heterotrimer association |
-, 740280 |
| 2.7.11.31 | H384A |
site-directed mutagenesis, mutation of beta subunit Gal83 causing a severe loss of function when assayed for growth on alternative carbon sources, the mutation does not affect heterotrimer association |
-, 740280 |
