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Results 1 - 7 of 7
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.361F184A/Y185A the mutations prevent enzyme degradation during S phase 754816
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.361H299A the mutation greatly impairs the enzymatic activity toward nucleosomal histone H4 753341
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.361R179A/K180A the mutations lead to similar enzymatic activity as the wild type equivalent and about 2.5fold decrease in nucleosome binding affinity 754422
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.361R179A/K180A/R188A/R189A the mutations produce similar enzymatic activity and even weaker nucleosome binding as compared to the R188A/R189A mutant 754422
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.361R188A/R189A the mutant has reduced nucleosome methyltransferase and much lower nucleosome binding activity (56% of full length, wild type enzyme activity, and 0.0025 mM nucleosome binding dissociation constant or over 300fold lower binding affinity compared to the equivalent wild type protein) 754422
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.361R265G inactive 754080, 754714
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.361S182F inactive 753385
Results 1 - 7 of 7
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