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Literature summary for 2.1.1.361 extracted from

  • Delaney, C.E.; Chen, A.T.; Graniel, J.V.; Dumas, K.J.; Hu, P.J.
    A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity (2017), Development, 144, 1273-1282 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.361

Protein Variants

Protein Variants Comment Organism
S182F inactive Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 Caenorhabditis elegans
-
 S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans Q09265
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
-
 Caenorhabditis elegans S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Synonyms

Synonyms Comment Organism
H4K20 methyltransferase
-
 Caenorhabditis elegans
histone H4 lysine 20 methyltransferase
-
 Caenorhabditis elegans
SET-4
-
 Caenorhabditis elegans

General Information

General Information Comment Organism
physiological function the enzyme is a sensory rheostat that reinforces developmental fates in response to environmental cues by modulating autocrine and paracrine DAF-2 insulin-like signaling. The enzyme acts specifically in the DAF-2/InsR pathway to promote dauer arrest in neurons Caenorhabditis elegans