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Information on EC 2.1.1.361 - [histone H4]-lysine20 N-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.361 [histone H4]-lysine20 N-methyltransferase
IUBMB Comments
The enzyme catalyses the monomethylation of the L-lysine20 residue of histone H4 (H4K20). This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase. This enzyme plays a pivotal role in DNA replication. Activity is high during the G2 and M phases, but declines significantly during G1 and S phases. Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.
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Word Map
  • 2.1.1.361
  • monomethylation
  • chromatin
  • trimethylation
  • monomethyltransferase
  • heterochromatin
  • crl4cdt2
  • polycomb
The expected taxonomic range for this enzyme is: Homo sapiens
Reaction Schemes
Synonyms
H4K20 protein lysine methyltransferase, histone lysine methyltransferase, KMT5a, PKMT, Pr-Set7, protein lysine methyltransferase, SET8, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
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