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Information on EC 2.1.1.361 - [histone H4]-lysine20 N-methyltransferase

for references in articles please use BRENDA:EC2.1.1.361

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IUBMB Comments

The enzyme catalyses the monomethylation of the L-lysine20 residue of histone H4 (H4K20). This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase. This enzyme plays a pivotal role in DNA replication. Activity is high during the G2 and M phases, but declines significantly during G1 and S phases. Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.

The enzyme appears in viruses and cellular organisms

Synonyms
setd8, pr-set7, kmt5a, suv4-20h2, suv4-20, set-4, h4k20 methyltransferase, pr-set7/9, histone h4-k20 methyltransferase, histone h4 lysine 20 methyltransferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
Highest Expressing Human Cell Lines
Cell Line Links Gene Links